Health Promotion, Primary Prevention
Conditions
Keywords
Aerobic exercise, Cardiorespiratory Fitness, High-intensity interval training (HIIT), Resistance training, Protein intake
Brief summary
The aim of this study is to investigate the effects of an 8-week high-intensity interval training (HIIT) or HIIT plus resistance training program combined with post-exercise protein supplementation on cardiorespiratory fitness and cardiometabolic risk indices in previously untrained individuals.
Interventions
DIETARY_SUPPLEMENTHIIT + protein
8-week supervised exercise program consisting of high-intensity interval training (HIIT). HIIT: 10x1 min at 85-95% HRmax divided by low intensity recovery periods. Three exercise sessions per week. Participants receive 40 g of a commercially available protein supplement administered as a shake after every exercise session.
DIETARY_SUPPLEMENTHIIT + placebo
8-week supervised exercise program consisting of high-intensity interval training (HIIT). HIIT: 10x1 min at 85-95% HRmax divided by low intensity recovery periods. Three exercise sessions per week. Participants receive 40 g of a commercially available iso-caloric placebo (Maltodextrin) administered as a shake after every exercise session.
DIETARY_SUPPLEMENTHIIT and resistance training + protein
8-week supervised exercise program consisting of high-intensity interval training (HIIT) and resistance training (RST). HIIT: 5x1 min at 85-95% HRmax divided by low intensity recovery periods. RST: 3-set resistance training using weight machines to train all major muscle groups with an individual intensity corresponding to 70-80% of one repetition maximum. Two exercise sessions per week. Participants receive 40 g of a commercially available protein supplement administered as a shake after every exercise session.
DIETARY_SUPPLEMENTHIIT and resistance training + placebo
8-week supervised exercise program consisting of high-intensity interval training (HIIT) and resistance training (RST). HIIT: 5x1 min at 85-95% HRmax divided by low intensity recovery periods. RST: 3-set resistance training using weight machines to train all major muscle groups with an individual intensity corresponding to 70-80% of one repetition maximum. Two exercise sessions per week. Participants receive 40 g of a commercially available iso-caloric placebo (Maltodextrin) administered as a shake after every exercise session.
Sponsors
University of Erlangen-Nürnberg Medical School
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
Randomized, double-blind placebo-controlled study. Participants and Outcome Assessors will not be aware of the arm to which the participants are allocated (double-blinded masking).
Intervention model description
Parallel Assignment Parallel Assignment parallel-group, randomized, double-blind, placebo-controlled study
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
• Sedentary Lifestyle over at least 6 months prior to the study
Exclusion criteria
* Pregnancy, Lactation * Psychological disorders, epilepsy, sever neurological disorders * Participation in other exercise- or nutrition studies within the last 6 months * coronary heart disease, heart failure * malignant disease * severe rheumatic or neurological disease * severe/unstable hypertension (resting RR: \>180/\>110 mmHg) * severely restricted lung function (FEV1 \<60%) * unstable Diabetes mellitus * severe orthopedic disease/restriction * acute / chronic infectious diseases * Electronic implants (defibrillator, pacemaker) * Persons in mental hospitals by order of authorities or jurisdiction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiorespiratory Fitness (CRF) | 8 weeks | CRF will be assessed by measuring maximum oxygen uptake (VO2max) |
| Muscle strength (only in groups with resistance training) | 8 weeks | Maximum strength (Fmax) of the major muscle groups (chest, upper back, lower back, abdominals and legs) will be estimated through submaximal tests, based on the performance of multiple repetitions. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardiometabolic Risk Score (MetS-Z-Score) | 8 weeks | MetS-Z-Score will be calculated from each individual's measures of waist circumference (cm), mean arterial blood pressure (mmHg), Glucose (mg/dL), triglycerides (mg/dL), and HDL-cholesterol (mg/dL), based on equations specific to sex. |
| Muscle mass | 8 weeks | Muscle mass (kg) will be measured by Bioelectrical Impedance Analysis (BIA) |
| Fat mass | 8 weeks | Fat mass (kg) will be measured by Bioelectrical Impedance Analysis (BIA) |
| Insulin sensitivity | 8 weeks | Insulin sensitivity will be estimated using homeostasis model assessment index (HOMA) |
| Inflammation status | 8 weeks | Inflammation status will be assessed by measuring blood levels (mg/L) of c-reactive protein (CRP) and high-sensitivity c-reactive protein (hs-CRP) |
| Health-related quality of life | 8 weeks | Health-related quality of life will be assessed by using the standardized and validated EQ-5D-5L Questionnaire, consisting of 2 pages: the EQ-5D descriptive system and the EQ visual analogue scale (EQ VAS). The descriptive system comprises five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each dimension has 5 levels: no problems, slight problems, moderate problems, severe problems and extreme problems. The patient ticks the box next to the most appropriate statement in each dimension (scale: 1-5; lower value = better outcome). The digits for the 5 dimensions can be combined into a 5-digit number that describes the patient's health state.The EQ VAS records the patient's self-rated health on a vertical visual analogue scale (0-100, higher value = better outcome). |
Countries
Germany
Contacts
Primary ContactDejan Reljic, Dr.
Backup ContactHans J Herrmann, Dr.
Outcome results
None listed