Acute Respiratory Distress Syndrome, COVID-19, Mechanical Ventilation Pressure High
Conditions
Keywords
ARDS, COVID-19, mechanical ventilation, PEEP
Brief summary
This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2\<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March 2020 were included. Epidemiological, clinical data, lung mechanics, artery blood gas test and hemodynamics at three methods to titrate PEEP, optimizing oxygenation, optimizing compliance, ARDSnet. The study was approved by the Ethics Committee of Zhongda Hsopital, Southeast University.
Detailed description
After PEEP titration, PEEP settings could be set by optimizing oxygenation, optimizing compliance, ARDSnet.
Interventions
OTHERGas exchanges at different PEEP
Gas exchanges measurement at different PEEP
OTHERlung mechanics at different PEEP
lung mechanics measurement at different PEEP
OTHERHemodynamics changes at different PEEP
Hemodynamics changes measurement at different PEEP
Sponsors
Southeast University, China
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* COVID-19 patients with mechanical ventilation * PO2/FIO2\<300mmHg * ages\>18 years
Exclusion criteria
* pneumothorax * pregnant * hemodynamics is unstable
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory system compliance improvement | 20 minutes | the respiratory system compliance was compared among three groups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gas echanges improvement | 20 minutes | P/Fwere compared among three groups |
Other
| Measure | Time frame | Description |
|---|---|---|
| hemodynamics improvement | 20 minutes | MAP were compared among three groups |
Countries
China
Outcome results
None listed