Autism Spectrum Disorder
Conditions
Brief summary
The investigators conduct the real world study to explore mechanisms of autism based on multi-modal data.
Detailed description
Children with autism spectrum disorder registered in Xinhua Hospital are measured in aspects of behavioural accessment, genetic test, blood lab test, gut microbiome and neuroimaging including structural and functional magnetic resonance imaging (MRI), functional near - infrared spectroscopy(f-NIRS), electroencephalography and eye movement. The investigators conduct the real world study to explore mechanisms of autism based on the multi-modal data.
Interventions
None listed
Sponsors
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Months to 18 Years
Inclusion criteria
* diagnosed with autism spectrum disorder * registered in Xinhua hospital * written informed consent provided
Exclusion criteria
* NA
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Behaviour assessment | The baseline and 3 months | The behaviour development of participants includes intellectual/developmental quotient, syptoms severity, comorbidity, etc. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Blood test | The baseline and 3 months | Retained blood samples tested in immunomics, metabonomics, etc |
| Gut mircobiome | The baseline and 1 months | Retained stool samples tested in metabonomics, genomics, etc |
| Head Magnetic Resonance Imaging (Head MRI) | The baseline and 3 months | Head MRI is used to detect the structure and function of the brain. |
| Genetic characteristics | The baseline | Genome wide association study from blood sample |
| Multichannel Electroencephalography signals | The baseline and 3 months | The latency and amplitude measured by electroencephalogram can reflect the connectivity between brain regions. |
| Eye movements | The baseline and 3 months | Variables measured by eye movements represent cognition. |
| Behaviour assessment | The baseline and 6 months | The behaviour development of participants includes intellectual/developmental quotient, syptoms severity, comorbidity, etc. |
| Functional near - infrared spectroscopy(f-NIRS) | The baseline and 3 months | Head fNIRs is a non-invasive, non-ionizing method for measuring and imaging the functional hemodynamic response to brain activity. It measures changes in hemoglobin (Hb) concentrations within the brain by means of the characteristic absorption spectra of Hb in the near-infrared range. |
Countries
China
Contacts
Primary ContactFei Li, doctor
Outcome results
None listed