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Maximum Expiratory Pressure in Induced Cough as a Predictor of Extubation Failure

Maximum Expiratory Pressure in Induced Cough as a Predictor of Extubation Failure in Intensive Care Unit Patients on Mechanical Ventilation Ready to Extubate. A Single-arm Open Clinical Trial.

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04356625
Enrollment
80
Registered
2020-04-22
Start date
2018-10-01
Completion date
2019-09-09
Last updated
2020-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Airway Extubation

Keywords

airway extubation, maximal expiratory pressure, induced cough, ventilator weaning

Brief summary

Clinical trial for the evaluation of diagnostic tests. The sample was composed of adults under mechanical ventilation who passed the spontaneous breathing trial and was ready to be extubated. The maximum expiratory pressure measured in the usual way and the maximum expiratory pressure generated during the induced cough were taken as predictor variables. The outcome variable was extubation failure, measured at 72 hours and at 7 days.

Detailed description

After completing the spontaneous breathing trial (SBT), with the extubation decision defined by the physician in charge of the patient and maximal expiratory pressure (MEP) as usually measured greater than 30 centimeters of water (cmH2O). Following this, the patient was allowed to rest for 5 minutes in the same condition. With the patient in the supine position sitting 45 ° to 60 °, the closed suction catheter was removed, an elbow was placed at 90 ° and a bacterial filter in series with the endotracheal tube (ET), an adapter was also coupled with a outlet port to the aneroid pressure gauge. In series an inspiratory unidirectional valve was placed that did not allow expiration. Immediately 2 ml of physiological solution was slowly instilled through the port in the 90º elbow to trigger the cough reflex. The presence or absence of reflex cough and the MEP during induced cough (MEPic) value were verified. As a safety method, the procedures were stopped if the patient presented signs of intolerance such as respiratory rate (RF)\> 35 breaths per minute, saturation \<90%, heart rate (HR)\> 140 beats per minute or increase of 20 % of resting levels.

Interventions

DIAGNOSTIC_TESTMEPic

* patient in the supine position sitting 45° to 60°, * closed suction catheter was removed * a 90° elbow was placed and a bacterial filter in series with endotracheal tube * adapter was also coupled to the aneroid pressure gauge * in series an inspiratory unidirectional valve was placed that did not allow expiration * 2 ml of physiological solution was slowly instilled through the port in the 90º elbow to cause induced cough

Sponsors

Hospital Nacional Profesor Alejandro Posadas
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE

Intervention model description

Single-arm clinical trial to establish diagnostic performance of MEPic

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Under mechanical ventilation via endotracheal tube in a period greater than 48 hours * Passing the spontaneous breathing trial an be ready for extubation. * Agree to participate in the study and sign the informed consent by the patient or family member

Exclusion criteria

* tracheostomized prior to admission to mechanical ventilation * history of neuromuscular disease * presence of unstable heart disease * received upper digestive surgery * presence of uncontained enterocutaneous fistula * candidates for non-invasive ventilation as a modality of interface exchange for extubation or as a preventive modality * patients who did not reach a MEP (habitual) of 30 cmH20 since they are not extubated by the extubation protocol of our institution.

Design outcomes

Primary

MeasureTime frameDescription
Extubation failure72 hoursEndotracheal tube removal failure

Countries

Argentina

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 10, 2026