Coronavirus Infection, COVID-19, Pneumonia
Conditions
Brief summary
Captopril being an effective drug available in liquid preparation, administration by nebulization could be of interest for maximizing lung action and minimizing systemic side effects. Such a treatment might be used for Covid-19 patients with pneumonia in order to avoid ARDS.
Detailed description
Coronavirus Disease 2019 (COVID-19) is due to SARS-CoV-2 infection. The main cause of death is refractory acute respiratory distress syndrome (ARDS) secondary to SARS-CoV-2 pneumonia. The SARS-CoV-2 may have specific virulence factors to achieve mortality rates around 3%. As the SARS-CoV, virus responsible of the Severe Acute Respiratory Syndrome in 2003 (which mortality was around 10%), the SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) as the receptor binding domain for its spike protein making ACE2 the gateway in the alveolar epithelial cells1. Angiotensin-converting enzyme (ACE) and ACE2 are known to be present in respiratory epithelium and to have antagonist physiological functions. ACE2 has an anti-inflammatory, anti-fibrosing role, anti-oxydant and vasodilatator activity, while ACE has the opposite characteristics. These two enzymes have a negative control on each other, one inhibiting the other. Demonstrated that SARS-CoV is responsible of a downregulation of ACE2 functions by using ACE2 as cell receptor2. While ACE2 is downregulated, ACE activity increase leading to more alveolar damage and acute respiratory failure. ACE inhibitors are common drugs used to treat hypertension worldwide. Using an ACE inhibitor as treatment against SARS-CoV-2 could be counter-intuitive because increasing ACE2 expression would open the cellular gate to the virus3,4. However, ACE2 was described as protecting lung injury2, leading Recombinant Human ACE2 as a perspective for SARS-CoV-2 treatment. A simple way to increase ACE2 in patients with SARS-CoV-2 pneumonia could be an inhalation of ACE inhibitor.
Interventions
DRUGcaptopril 25mg
Drug administration
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Hospitalization for acute respiratory failure requiring oxygen administration ≥3L/mn 2. Age \> 18 years or older 3. Presence of pneumonia 4. PCR SARS-CoV-2 positive in any biological sample in the last 7 days 5. Patient affiliated to social security regime 6. Written informed consent provided by the patient or alternatively by next-of-kin, or in emergency situations, prior to any protocol-specific procedures
Exclusion criteria
1. Decision of withholding invasive mechanical ventilation 2. Shock requiring vasopressor infusion 3. Co-infection with another respiratory pathogen which could be responsible of pneumonia 4. Hypersensitivity to captopril, to any other angiotensin converting enzyme inhibitor or any of the excipients of the specialty used 5. History of angio-oedema 6. History of ACE-inhibitor allergy 7. Known pregnancy or current lactation: Female subject of childbearing potential should have a negative serum pregnancy test prior to receiving the first dose of study medication. 8. Patient who is currently enrolled in other investigational study; 9. Persons deprived of their liberty by judicial or administrative decision, 10. Persons under legal protection/safeguard of justice, 11. Patients under duress psychiatric care, 12. Persons admitted to a health or social institution 13. Patient on state medical aid
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy of captopril nebulization addition to standard of care compared to standard of care. | 14 Days | To assess determine the efficacy of captopril nebulization addition to standard of care compared to standard of care in term of 14-day ventilation free survival |
Countries
France
Contacts
Primary ContactMohammed RAHAOUI, PM
Backup ContactYacine TANDJAOUI-LAMBIOTTE, MD
Outcome results
None listed