Heparin, Perioperative
Conditions
Brief summary
Heparin diluent or normal saline is generally used as the arterial tube flushing in clinical practice, but there is no consensus on the choice of flushing fluid. Heparin can affect the blood coagulation function, and even lead to heparin-related thrombocytopenia, increasing the risk of perioperative embolism. Sonoclot is a blood viscoelasticity test, which can provide comprehensive information on the coagulation's cascade and the entire process and be quicker and more effective than routine laboratory coagulation tests. In this research, the coagulation and platelet function analyzer called Sonoclot is used to evaluate the effect of different concentrations of pressurized heparin on the coagulation and platelet function of perioperative patients, which can provide a reference for the clinical choice of appropriate arterial flushing.
Interventions
DRUGHeparin
heparin with a concentration of 2 U/ml is used for pressurized continuous flushing of the invasive arterial pressure monitoring tube
DRUGnormal saline
normal saline is used for pressurized continuous flushing of the invasive arterial pressure monitoring tube
Sponsors
Yangzhou University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Diagnosis of gastrointestinal cancer * Ages ranged from 18 to 75 * ASA I\ III
Exclusion criteria
* Pregnancy * modified Allen Test negative * history of taking anti-platelet drugs such as aspirin one week before surgery, heparin allergy and thrombotherapy * two failed catheterizations of the same artery * significant diseases in liver and kidney function * refusal of patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The level of glass bead Activated Clotting Time | through study completion, an average of 3 minute | 10 min after the vein puncture, 2 h after skin incision and at the end of surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The level of glass bead Platelet Function | through study completion, an average of 3 minute | 10 min after the vein puncture, 2 h after skin incision and at the end of surgery |
| The level of platelet count | through study completion, an average of 2 minute | 24 h after surgery and 48 h after surgery |
| The level of glass bead Clot Rate | through study completion, an average of 3 minute | 10 min after the vein puncture, 2 h after skin incision and at the end of surgery |
| The amount of infusion volume, blood loss, urine volume | intraoperative | — |
| The appearance of local complications of arterial puncture | within 24 h after surgery | Yes or No |
| The frequencies of hand positional changes and manual artery flushing | intraoperative | — |
Countries
China
Outcome results
None listed