Taking Charge of Cognitive Impairment in Patients With Mood Disorders
Conditions
Brief summary
Psychotherapeutic management of cognitive disorders in patients suffering from a mood disorder
Interventions
BEHAVIORALEvaluation
Evaluation of a cognitive remediation program for mood disorders
Sponsors
Centre hospitalier de Ville-Evrard, France
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Intervention model description
Evaluation of the specific therapeutic efficacy of Cognitive Training Therapy for Bipolar Patients on cognitive deficits in patients with bipolar disorder, treated over three months and followed up over nine months. Randomized, double-blind study.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Age between 18 and 65 years old 2. The patient's previous diagnosis of Bipolar-Related Disorder or Depressive Disorder according to the DSM-5 criteria. 3. Mood stabilized with respect to depressive symptomatology (absence or presence of residual mild depressive symptoms (HDRS-17 ≤ 18)) 4. Mood stabilized with respect to manic symptomatology (absence or presence of residual mild manic symptoms (YMRS ≤ 8)) 5. Stable and effective treatment at minimum dose for at least 2 months 6. Cognitive complaint expressed by the patient, and detected by the patient's referring psychiatrist 7. Free and Informed Consent Form read, initialled and signed 8. Patient affiliated to a social protection scheme or beneficiary of State Medical Aid 9. Patient knowing how to speak French -
Exclusion criteria
1. Presence of a DSM-5 disorder, other than a mood, anxiety or personality disorder 2. Substance addiction or abuse (Alcohol, psychoactive substances) in the past 12 months 3. Manic, hypomanic or major depressive episode in the last 2 months 4. Somatic or neurological disorder which may lead to cognitive impairment 5. Current or less than one month's commitment to another research protocol 6. A neuropsychological assessment prior to 6 months. 7. Patient under protective custody, guardianship or reinforced guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the Perceptual Reasoning Index (PRI) the Wechsler Intelligence Scale. | at 1 year | Increase in the Perceptual Reasoning Index (PRI) of the Wechsler Adult Intelligence Scale - Fourth Edition \[WAIS-IV\] significantly different between the two study groups. |
Countries
France
Contacts
Primary ContactYoucef BENCHERIF
Outcome results
None listed