Qualitative and Quantitative Evaluation of Anosmia Over Time in Clinically Symptomatic Patients Tested for COVID-19 Infection

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04354857

Acronym

Anosmie-COVID

Enrollment

454

Registered

2020-04-21

Start date

2020-03-27

Completion date

2020-11-30

Last updated

2021-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19

Keywords

anosmia, SARS-Cov-2

Brief summary

Loss of sense of smell and taste has been anecdotally reported during the covid-19 epidemic. The study investigators wanted to describe the prevalence of olfactory and gustatory dysfunction and assess the factors associated with positive SARS-CoV-2 infection.

Interventions

OTHERolfactory and gustatory tests

Participants rate quality of sense of smell and taste. Olfaction test: Sniff 10ml test tube containing 1.5ml air freshner (Mifleur Citron, Coldis, Entraigues sur Sorgues, France) and rate perception of odor. Gustatory test: Taste a pinch and sugar and salt and rate perception of sweet or salty taste

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients presenting with COVID-19 related symptoms including: fever, persistent cough, fatigue, shortness of breath, diarrhoea, abdominal pain, chest pain, sore throat, loss of smell or taste * Subjects in prolonged contact with COVID-19 infected patients.

Exclusion criteria

* Patients directly admitted to the intensive care unit were excluded * Patients opposing use of their health data

Design outcomes

Primary

Measure	Time frame	Description
SARS-CoV-2 infection status	Day 0	Positive/negative according to RT-PCR assay
Olfactory and gustatory loss	Day 0	Custom-designed questionnaire (28 questions pertaining to symptoms, sense of smell and taste)

Secondary

Measure	Time frame	Description
Ability to detect sweet taste	Day 0	Ability to taste a pinch of sugar on a 0-100 VAS scale
Ability to detect odor	Day 0	Ability to smell 1.5ml air freshner on a 0-100 VAS scale
Severity of infection according to hospitalization rate	End of study (six months)	% patients hospitalized
Olfactory and gustatory loss	Day 7	Custom-designed questionnaire (28 questions pertaining to symptoms, sense of smell and taste)
Ability to detect salty taste	Day 0	Ability to taste a pinch of table salt on a 0-100 VAS scale

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026