Child, Only, Infant, Newborn, Diseases, Critical Illness, ARDS, Human, Heart Defects, Congenital, Lung Diseases, Obstructive, Lung Diseases, Interstitial
Conditions
Keywords
capnography, end-tidal CO2, critically ill children, ventilated, accuracy
Brief summary
End-tidal CO2 measurements in children will be assessed for their accuracy with arterial CO2 measurements.
Detailed description
End-tidal and arterial CO2 measurements will be performed in invasively and non-invasively ventilated critically ill children. The endtidal CO2 values will assessed for their accuracy with respect to different underlying diseases and conditions of the children.
Interventions
DIAGNOSTIC_TESTcapnography monitoring
routinely used capnography monitoring
DIAGNOSTIC_TESTarterial blood gas
Routinely taken arterial blood gas values
Sponsors
Vincenzo Cannizzaro
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Hours to 13 Years
Healthy volunteers
Yes
Inclusion criteria
* Children on pressure controlled mechanical invasive or non-invasive ventilation on the Paediatric Intensive Care Unit of the University Children's Hospital Zurich * Newborns with a birthweight of at least 2.0 kg * Newborns with an age of at least 1 hour (age \> 60 minutes) * Children up to the last day of the 13th year of living * Ability of care taker or patient to understand verbal and written instructions and the general consent or informed consent in German or English * Obtained written general or informed consent as documented by signature * Available arterial line, i.e. a specific catheter inserted in an artery
Exclusion criteria
* Care taker or participant unable for linguistic, mental or other reasons or unwilling to understand verbal or written information and to give written informed consent in German or English * Care taker not available * Newborns with a birthweight below 2.0 kg * Newborns younger than 1 hour (age \<60 minutes) * Children with an age of 14 years onwards * Missing arterial line * Patients dependent on any other kind of respiratory support that is not compatible with the PcCO2-sensor or where a high leakage in the respiratory circuit makes PcCO2 measurements impossible (nasal mask ventilation, low-flow-/high-flow-ventilation, rebreathing mask, high- frequency-oscillation) * Patients where the investigators act on the assumption that mechanical ventilation will be discontinued and/or the arterial line will be removed within 6 hours or where only one pair of values (arterial and endtidal CO2) can be compared * Patients with a cyanotic shunt lesion with a weight of 15 kg or above
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Accuracy of end-tidal Carbon Dioxide (PetCO2) values in comparison to arterial Carbon Dioxide (PaCO2) values in invasively and non-invasively ventilated critically ill children without lung or heart disease | On average every participant will be assessed for 5 days | Mean absolute measurement difference between simultaneously obtained PaCO2 and PetCO2 values (bias) and their 95% limits of agreement (precision) in children and newborns without cardiopulmonary dysfunction. Units of measure will be in kilopascal (kPa) for PetCO2 and PaCO2, respectively. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Accuracy of end-tidal Carbon Dioxide (PetCO2) values in comparison to arterial Carbon Dioxide (PaCO2) values in invasively and non-invasively ventilated critically ill children with lung and or heart disease | On average every participant will be assessed for 5 days | Cardiopulmonary function-dependent mean absolute measurement difference between simultaneously obtained PaCO2 and PetCO2 values (bias) and their 95% limits of agreement (precision) in children and newborns with cardiopulmonary dysfunction. Units of measure will be in kilopascal (kPa) for PetCO2 and PaCO2, respectively. |
Countries
Switzerland
Outcome results
None listed