Assessing Muscle Metabolic Phenotype by MSK Ultrasound

Assessment of Muscle Metabolic Phenotype by the Use of Point-of-care MSK Ultrasound Imaging.

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04353648

Enrollment

Registered

2020-04-20

Start date

2019-11-01

Completion date

2020-03-05

Last updated

2024-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CT, MuscleSound, Ultrasound

Brief summary

The purpose of this study is to test whether ultrasound images (pictures) can be used as a valid assessment of muscle quality in different muscle groups during Intensive Care stay. This new approach would allow clinicians to obtain frequent skeletal muscle images and would enable doctors to observe any changes over time in muscle quality that could occur during ICU stay. Participants in this study will have ultrasound images made of their leg-, chest- and jaw muscles taken on every day until ICU discharge.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* admission Duke Trauma center, SICU, MICU, or CT ICU * \>18 years of age

Exclusion criteria

* \<18 years of age * prisoners

Design outcomes

Primary

Measure	Time frame	Description
Muscle Quality from the rectus femoris, vastus lateralis, intermedius, intercostalis, temporalis and styloglossus	Minimum of every other day while in ICU (up to 10 days). Once discharged from ICU minimum of 3x a week until discharge (up to 3 weeks)	Ultrasound-derived area of intramuscular adipose tissue (IMAT) and intramuscular glycogen content from the rectus femoris, vastus lateralis, intermedius, intercostalis, temporalis and styloglossus
Muscle volume and thickness from the rectus femoris, vastus lateralis, intermedius, intercostalis, temporalis and styloglossus	Minimum of every other day while in ICU (up to 10 days). Once discharged from ICU minimum of 3x a week until discharge (up to 3 weeks)	Ultrasound-derived volume and thicknessfrom the rectus femoris, vastus lateralis, intermedius, intercostalis, temporalis and styloglossus

Secondary

Measure	Time frame	Description
Changes of Intramuscular adipose tissue (IMAT) content and muscle volume/thickness from the psoas at the Level of L3/L4	Up to 1 year	the change over time of (standard of care) CT-derived area of intramuscular adipose tissue in cm2
Changes of Intramuscular adipose tissue (IMAT) content and muscle volume/thickness from the intercostal muscle at the Level of Th3/Th4	Up to 1 year	the change over time of (standard of care) CT-derived area of intramuscular adipose tissue in cm2
Changes of Intramuscular adipose tissue (IMAT) content and muscle volume/thickness from the intercostal muscle at the Level of the head	Up to 1 year	the change over time of (standard of care) CT-derived area of intramuscular adipose tissue in cm2

Countries

United States

Outcome results