Amoxicillin, Metronidazole, Ofloxacin, Periodontitis, Root Planing
Conditions
Brief summary
Context and Aims: Several studies have demonstrated an association between obesity, periodontitis, and exercise. This study aimed to investigate the effects of regular exercise on obese women with periodontal disease, using serum, saliva, and gingival crevicular fluid (GCF) samples. Settings and Design: A before-after study design was adopted to evaluate the effects of 12 weeks of regular exercise on obese women grouped according to periodontal status, without a control group (no exercise). Methods and Material: The study sample comprised fifteen patients without periodontitis (NP group) and 10 patients with chronic periodontitis (CP group), from whom periodontal parameters were measured and serum, saliva, and GCF samples were collected. Body mass index (BMI), anthropometric measurements, somatotype-motoric tests, and maximal oxygen consumption (VO2max) were recorded at baseline and after exercise. Statistical analysis used: MedCalc was used for statistical analysis.
Interventions
DRUGOfloxacin
400 mg, 1 time per day for 5 days
DRUGAmoxicillin
500 mg, 3 times per day for 7 days
DRUGMetronidazole
500 mg, 3 times per day, for 7 days
Sponsors
Istanbul Medipol University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* The periodontal diagnosis of participants with generalized periodontitis stage III-IV/grade C. Systemically healthy participants with generalized periodontitis were enrolled if they were between 18 and 40 years of age, and had no allergies to penicillin, metronidazole or quinolones, a history of antibiotic therapy or periodontal therapy within the preceding six months
Exclusion criteria
* Subjects were excluded if they had any known systemic diseases or conditions that can/could influence the periodontal status, allergies to quinolones, penicillin or metronidazole, a history of antibiotic therapy, or periodontal treatment within the preceding six months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Probing depth | 6-months | Probing depth was recorded at the baseline, first, third, and sixth month. The changes were evaluated among and between groups. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical attachment loss | 6-months | Clinical attachment loss was recorded at the baseline, first, third, and sixth month. The changes were evaluated among and between groups. |
Countries
Turkey (Türkiye)
Outcome results
None listed