Allergic Rhinitis, Allergic Asthma
Conditions
Brief summary
This study aims to investigate immune mechanisms and phenotypes and endotypes of allergic airway diseases - allergic rhinitis and allergic asthma. Pathogenesis of these diseases are not fully investigated yet. Patients with the same disease have different dominant symptoms, course of the disease and response to treatment. Moreover, there is a hypothesis about united airway disease suggesting that allergic rhinitis and allergic asthma is different manifestation of the same disease. This led to assumption of phenotypes and endotypes. This classification which still is not unified can let to prescribe personalized treatment for every patient.
Interventions
PROCEDURENasal provocation test
Allergen extract under controlled conditions will be applied into nasal mucous.
Sponsors
Lithuanian University of Health Sciences
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Hypersensitivity to house dust mites * Allergic rhinitis with or without mild to moderate asthma
Exclusion criteria
* Acute or chronic infections * Use of systemic immunosupresants (wait 1 month) * Use of systemic or local antihistamines (wait 1 week) * Use of intranasal steroids (wait 1 month) * Oncological or active autoimmune diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cytokines level in nasal lavage and peripheral blood after nasal provocation test in different groups. | 2 hours | Cytokines (IL-13, IL-10, IL-22, etc.) level will be measured by ELISA before and after nasal provocation test with house dust mites. Comparison between different groups. |
Countries
Lithuania
Contacts
Primary ContactLaura Tamasauskiene, MD
Backup ContactBrigita Sitkauskiene
Outcome results
None listed