SARS-CoV 2
Conditions
Keywords
Survival, Covid-19, Aged subjects, Zinc, 25-OH cholecalciferol
Brief summary
Mortality from Covid-19 increases with age, reaching 14.8% from the age of 80. The severity of the infection is linked to the acute respiratory distress syndrome (ARDS) which requires intensive care. ARDS is the consequence of the reactional inflammatory storm that damages the lungs. Aged subjects are particularly prone to zinc and vitamin D deficiency. These two micronutrients are able to modulate the immune response by reducing the inflammatory storm. The hypothesis is that supplementation with zinc and vitamin D would reduce the inflammatory reaction which worsens ARDS and leads to the death of subjects infected with Covid-19.
Interventions
DIETARY_SUPPLEMENTZinc gluconate
Zinc gluconate capsule 15 mg x 2 per day during 2 months
DIETARY_SUPPLEMENT25-OH cholecalciferol
25-OH cholecalciferol drinkable solution 10 drops (2000 IU) per day during 2 months
Sponsors
University Hospital, Lille
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Institutionalized
Exclusion criteria
* Life expectancy \< 1 month independently of Covid-19 infection (overall subjects) * Known hypercalcemia * History of renal lithiasis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival rate in asymptomatic subjects at inclusion | Two months after inclusion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Survival rate in symptomatic subjects at inclusion | Two months after inclusion | — |
| Survival rate in overall subjects | Two months after inclusion | symptomatic subjects and asymptomatic subjects |
| Cumulative incidence of Covid-19 infection in asymptomatic subjects at inclusion | Within two months after inclusion | — |
Outcome results
None listed