Ocular Surface Disease, Osteoarthritis, Diacerein
Conditions
Keywords
Dry Eye Syndromes, Osteoarthritis, Ocular surface inflammation, Interleukin-1, Interleukin-1 receptor antagonist
Brief summary
Dry eyes is multi-factorial disease which inflammation play etiological role. Diacerein is drug which has anti-inflammatory effect by antagonist Interleukin-1, decrease Interleukin-1 receptor, increase Interleukin-1 Receptor antagonist. This observational study enrolled participants who going to take diacerein for osteoarthritis, measure corneal staining score, Ocular surface disease index score, Tear Osmolarity, Tear break up time, Schirmer 1 test, Interleukin-1 Receptor antagonist, Interleukin-1 alpha, Interleukin-1 beta level in tear at the time of enrollment and after 2 months.
Interventions
DRUGDiacerein
Diacerein prescribing by orthopedist. Dry eye sign and symptom was asses before start diacerein and after 2 months.
Sponsors
Chulalongkorn University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Osteoarthritis with 2. Ocular surface index score ≥ 13 with 3. Corneal staining score ≥ 3
Exclusion criteria
1. Allergic to diacerein 2. Use Cyclosporin within 30 days 3. Eyelid problem 4. Change artificial tear while in the study 5. Pregnancy or breast feeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Corneal staining score change from baseline at 2 months | At the time of enrollment and 2 months | Stain Cornea with Fluorescine, count and score staining at the cornea according to National eye institute : score 0-15 (0=no staining) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ocular surface disease index score | At the time of enrollment and 2 months | Ocular Surface Disease Index : 0-100 (0=no any symptom) |
| Tear Osmolarity | At the time of enrollment and 2 months | Use Tearlab to measure tear osmolarity |
| Tear break up time | At the time of enrollment and 2 months | Stain Cornea with Fluorescine, wait until tear film break, record time that tear break |
| Schirmer 1 test | At the time of enrollment and 2 months | place Schirmer strip at the fornix without anesthesia, wait for 5 min, record tear distance |
| Interleukin-1 receptor antagonist, Interleukin-1 alpha, Interleukin-1 beta level in tear | At the time of enrollment and 2 months | Extract tear from Schirmer strip and use Bioplex for cytokine measurement of Interleukin-1 receptor antagonist(picogram/ml), Interleukin-1 alpha(picogram/ml), Interleukin-1 beta(picogram/ml) |
Countries
Thailand
Outcome results
None listed