Chronic Obstructive Pulmonary Disease, Heart Failure
Conditions
Brief summary
INTRODUCTION: The complexity of the pathophysiology of heterogeneous diseases such as heart failure and obstructive pulmonary disease causes a different approach to these diseases or with a view as much as a better understanding of the same situations, with which the clinical profile of patients who are associated with an association is. It is known that regular physical training promotes progressive improvements in exercise tolerance, in the pulmonary ventilation / perfusion ratio and in respiratory function by strengthening. OBJECTIVE: To compare the effects of high-intensity interval training and continuous aerobic exercise, with peripheral endothelial function, brain natriuretic peptide levels, maximum exercise tolerance, distribution of lung volumes and quality of life of patients with obstructive pulmonary disease associated with heart failure. METHODS: This is a clinical, controlled, randomized and blinded trial. Peripheral endothelial function, tolerance to maximum and submaximal exercise, distribution of lung volumes, quality of life, presence of symptoms of depression and perception of clinical change will be evaluated. EXPECTED RESULTS: Incorporate into the care of these patients, new effective therapeutic approaches, of low cost and with greater technical and scientific evidence.
Interventions
OTHERHigh-intensity interval training
Exercise with high-intensity intervals followed by active rest
Interval Moderate-intensity aerobic training without intervals
Sponsors
Universidade Federal de Pernambuco
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Sedentary individuals with Heart Failure of all etiologies; * Diagnosed moderate and severe chronic obstructive pulmonary disease; * Clinical stability; * No change in the medication class within three months before the beginning of the research.
Exclusion criteria
* Unstable angina; * Myocardial infarction; * Previous cardiac surgery up to three months before the beginning of the study; * Hemodynamic instability; * Orthopedic and neurological diseases; * Psychological and/or mental impairment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exercise tolerance | 24 weeks | Evaluated by the cardiopulmonary exercise test by measuring the maximum oxygen consumption. |
| Peripheral endothelial function | 24 weeks | Evaluated by the peripheral arterial tonometry using the EndoPat 2000 device |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quality of life assessment: Short Form-36 questionnaire | 24 weeks | Evaluated by the Short Form-36 questionnaire |
| Distance covered in the six-minute walk test | 24 weeks | Evaluated by the six-minute walk test |
| Perception of clinical change | 24 weeks | Evaluated by the Patient Global Impression of Change Scale which is a one-dimensional measure in which individuals can rate their associated improvement on a 7-item scale ranging from 1 = no changes to 7 = much better. |
Countries
Brazil
Outcome results
None listed