Coronavirus, COVID, COVID-19
Conditions
Brief summary
Given the high prevalence of COVID19 illness (both SARS-CoV-2 RT-PCR confirmed and highly suspect cases) among healthcare workers (HCW) within the Montefiore Health System (MHS), hydroxychloroquine (HCQ) will be prescribed to healthcare workers who are at the highest risk for severe COVID19 illness.
Interventions
DRUGHydroxychloroquine
400 mg tablet
Sponsors
Montefiore Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Symptomatic with COVID illness (either RT-PCR test confirmed or highly suspect clinical symptoms) * Call into office within the first 7 days of illness * Have any of the following high risk conditions: * Age \>60 * HTN, CAD, or chronic heart disease * Diabetes * Chronic kidney disease * Chronic lung disease * Active or recent chemotherapy for malignancy * Organ transplant * Taking Immune-suppressing medications * HIV with CD4 \<200 cells/mm3 * Experiencing at least one of the following high risk symptoms: * Severe cough * Fever 100.0F or greater * Diarrhea * Shortness of Breath * Hypoxia
Exclusion criteria
• HCW not meeting high-risk criteria or those with a contraindication to HCQ will not be offered HCQ
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to resolution of symptoms | up to 4 weeks | Time that it takes for symptoms to be resolved in those who were treated vs untreated |
Secondary
| Measure | Time frame |
|---|---|
| Number of days from onset of illness to symptom resolution | up to 4 weeks |
| Number of days to return to work | up to 4 weeks |
| Rate of hospital admission in treated and untreated healthcare workers | up to 4 weeks |
| Adverse effect of HCQ during treatment | up to 5 days |
Countries
United States
Outcome results
None listed