Fast Troponin as a Biomarker to Assess Exercise-induced Muscle Damage in Muscle Diseases

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04349566

Enrollment

Registered

2020-04-16

Start date

2020-06-01

Completion date

2021-12-20

Last updated

2022-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Becker Muscular Dystrophy, Limb-Girdle Muscular Dystrophy Type 2, McArdle Disease

Brief summary

The purpose of the study is to explore the biomarker Fast Troponins response to exercise in patients with Becker muscular dystrophy, Limb-girdle muscular dystrophy and McArdle disease

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* The ability to cycle * No concurrent medical condition that could interfere with interpretation of the results * Molecular diagnosis of the specific condition in specified patient groups or healthy control * No active muscle injury on the test day (caused by recent exercise, seizures, trauma, etc.)

Exclusion criteria

* Competing conditions at risk of compromising the results of the study * Cardiac or pulmonary disease contraindicating peak exercise testing or strenuous exercise * Veins that are too difficult to puncture for blood sampling, evaluated by the investigator * Severe muscle weakness, that prevents the subject completing the exercise test, evaluated by the investigator

Design outcomes

Primary

Measure	Time frame	Description
Change in biomarkers	24 hours	Change in Fast and slow Troponin I after muscle damage

Countries

Denmark

Outcome results