Pregnancy
Conditions
Keywords
triglycerides, glucose, adiposity, Air displacement plethysmography, Continuous glucose monitoring
Brief summary
This study plans to learn more about how an omega-3 fatty acid supplement effects triglyceride levels in pregnancy. Triglycerides are a type of fat found in your blood. Your body converts extra calories into triglycerides to be stored and used later for energy. It is normal for triglyceride levels to go up during pregnancy however some women have levels that are \ 30-40% higher than normal when they reach their third trimester of pregnancy. Having high triglycerides in pregnancy may be related to an increased chance of having a baby that is large for their age. The goal of this study is to determine if taking an omega-3 fatty acid supplement can slow the rise in triglyceride levels later in pregnancy.
Interventions
DIETARY_SUPPLEMENTIntervention Omega 3 Supplementation
Participants will supplement 4g of Omega 3 fish oil daily (750DHA/250EPA)
DIETARY_SUPPLEMENTPlacebo Soybean Oil
Participants will supplement 4g of Soybean oil daily
Sponsors
University of Colorado, Denver
University of Oklahoma
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
0 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
* Pregnant women between the ages of 21-39 yrs * Pre-pregnancy BMI 28-39 * Fasting Triglyceride ≥120 mg/dL measured by 15 wks
Exclusion criteria
* Pre-gestational diabetes or prediabetes * History of gestational diabetes, * History of pre-eclampsia, spontaneous pre-term delivery, or gestational hypertension \<34wks * Tobacco or illicit substance use * Chronic steroid use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maternal Fasting and Postprandial Triglycerides | 34 weeks gestational age | Differences in maternal fasting and postprandial triglycerides between groups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mesenchymal Stem Cell Differentiation | Delivery | Differences in Wnt/β-catenin signaling in mesenchymal stem cells between groups |
| Placental Nutrient Transport Capacity | Delivery | We will evaluate placental nutrient-sensing pathways that regulate transporter activity by measuring the abundance and phosphorylation of key components of the insulin/PI3K/Akt and mTOR signaling pathways, including Akt, mTOR, 4E-BP1, and S6K/rpS6, to determine whether O-3 FA supplementation improves placental nutrient sensing and transport regulation. |
| Nutrient Transport Gene expression | Delivery | Between-group differences in the expression of placental nutrient transporters GLUT1, GLUT4, FATP2, FATP4, FATP6, and FAT/CD36, and SNAT1, SNAT2, SNAT4, LAT1, LAT2. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORTeri L Hernandez, PhD
University of Colorado, Denver
Outcome results
None listed