Bronchopulmonary Dysplasia, Preterm Infant, Thrombocytopenia
Conditions
Brief summary
To investigate the relationship between bronchopulmonary dysplasia and thrombocytopenia.
Detailed description
A prosepective case-control study ,the case were matched with 1:1according to gestational age,birth weight and admission diagnosis and divided into two groups according to the consensus definition of National Institute of Child Health and Human Development (NICHD). Platelet count, circulating megakaryocyte count, platelet activating markers (CD62P and CD63), thrombopoietin were recorded and compared in two groups, then, serial thrombopoietin levels and concomitant platelet counts were measured in infants with BPD.
Interventions
OTHERBPD
It is a observation research.we didn't intervene anything.
Sponsors
yangjie
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
1. presence of clinical and radiologic signs of BPD, according to conventional criteria (Greenough, 1992); 2. presence of peripheral arterial catheter; 3. gestation \<32 weeks; 4. birth weight \<1.5 kg; 5. requiring mechanical ventilation for the treatment of respiratory distress syndrome for at least 3 days during the first weeks of life; 6. ventilator and/or oxygen dependent at time of enrolment;
Exclusion criteria
1. congenital abnormalities; 2. infection (bacteria infection confirmed by positive blood culture or viral infection confirmed by serological test or viral culture) 3. evidence of complications of perinatal asphyxia including an apgar score \<3 at one or five minute after birth, evidence of hypoxic-ischemic encephalopathy, acute tubular necrosis, or transient myocardial ischemia; 4. identifiable hematologic disease;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Platelet counts and Circulating MK counts | up to 4 weeks | Platelet counts and Circulating MK counts |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| CD62P and CD63 expression | up to 4 weeks | CD62P and CD63 expression |
| TPO | up to 4 weeks | Plasma TPO concentration |
| TPO and platelet | up to 6 weeks | the relationship betweenTPO concentration and Platelet counts in BPD with thrombocytopenia |
Countries
China
Outcome results
None listed