Healthy Aging
Conditions
Brief summary
The study examines the effect of cocoa flavanols, red-berries anthocyanins or a combination of both on markers of cardiovascular health and cognition.
Detailed description
The study examines the effect of cocoa flavanols, red-berries anthocyanins or a combination of both on markers of cardiovascular health and cognition. Healthy volunteers are recruited to participate in a parallel study (n 30 per group) for 10 to 12 weeks. Markers of cardiovascular health (FMD, markers of inflammation and fatty acid metabolism) and cognition (neuropsychological tests and plasma neurotrophins) are being measured before and after intervention.
Interventions
OTHERCocoa flavanols and berries anthocyanins
Effect of cocoa flavanols and berries anthocyanins on cardiovascular and cognitive health
Sponsors
Hospital Universitario 12 de Octubre
National Research Council, Spain
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 50-85 * BMI 20-32 Kg/m2
Exclusion criteria
* Mini-mental state examination (MMSE) \< 28 * Systolic blood pressure (SBP) \>139 mmHg * Diastolic blood pressure (DBP) \> 89 mmHg * Total cholesterol \> 6.5 mmol/L
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline of flow-mediated vasodilatation (FMD) of the brachial artery | Over 6 minutes on day 0 and after10 weeks | The FMD of the brachial artery will be measured using an ultrasound collected at baseline and continuously for 60 seconds post-arm occlusion for 5 minutes. FMD will be expressed as percentage of variation between pre-and postischemic diameters |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline STROOP score after 10 weeks intervention | at inclusion and 10 weeks after intervention | STROOP tests attention and executive function. This test aims to evaluate the inhibition of an automated process such as reading by asking participants to name the color of color names written in a different color ink. For each participant SROOP results at inclusion will be compared with results after 10 weeks intervention |
| Change from baseline Tower of London score after 10 weeks intervention | at inclusion and 10 weeks after intervention | Tower of London test consist of a three color game board that allows executive functioning evaluation by total time, time to first move and optimal moves change from participants inclusion to week 11. |
Countries
Spain
Outcome results
None listed