Non-healing Wound
Conditions
Brief summary
Investigator is studying the effects of Lidocaine and Adrenaline Soaked Gauze vs Normal Saline Soaked Gauze at Skin Graft Donor Site of Thigh. Haemostatic effect, epithelization and post operative pain will be assessed on follow up.
Detailed description
After admission participants will be randomized either to be in Group A or Group B. Closed envelop technique will be used for random assignment of the patients. Group A will be receiving 2% lidocaine and 1:100,000 adrenaline soaked gauze while group B will be given only normal saline soaked gauze at donor-site for ten minutes. The primary end point of study is intraoperative bleeding. The secondary end points of study include no. of dressings required in first 24 hours after surgery, donor site epithelization at 14th post-operative day, post-operative pain in first 24 hours after surgery along with systemic analgesia requirement after surgery.
Interventions
DRUG2% Lidocaine and 1:100,000 Adrenaline
Topical application of 2% Lidocaine and 1:100,000 Adrenaline in the form of dressing will be applied over skin graft donor site of thigh for 10 minutes.
DRUGNormal saline
Topical application of Normal saline will be applied over skin graft donor site of thigh as a control group.
Sponsors
Dow University of Health Sciences
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Masking description
Patients will be recruited in the study by closed envelope technique and the study will be single blinded.
Intervention model description
Patients with non healing wound who will otherwise be healthy will be recruited in the study and will randomly assign groups. One group will receive Adrenaline and Lidocaine soaked gauze and the second group will be a control group who will receive normal saline soaked gauze.
Eligibility
Sex/Gender
ALL
Age
15 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* • Patients of both the gender of age \> 15 years * Multiple donor-sites
Exclusion criteria
Bleeding disorder * Concomitant injuries * Donor site other than thigh * Previously harvested donor-site * Patients on antiplatelet medications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intra operatieve bleeding | per operative | Intra-operative Bleeding from donor site of graft will be assessed per operatively as being normal or more than normal. |
| Post operative bleeding | 24 hours | post operative bleeding will be assesd in post operative period by number of dressings required. |
| Post operative pain | 24 hours | post operative pain will be assessed in the post operative period by visual analog score. Score ranges from 0 to 10 with 0 indicating no pain whereas 10 is worst pain. |
| Analgesia requirement | 24 hours | Post operative analgesia requirement of patient will be observed by number of medications required |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Epithelization of donor site | 14 days | Epithelization over donor site will be assessed on 14th post operative day by subjective assesment |
Countries
Pakistan
Outcome results
None listed