Assessment of Chilbains Occuring During Covid-19 Infection

Assessment of Skin Manifestations Occuring During Covid-19 Infection With a Special Focus on Chilbains

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04344119

Acronym

ChilblainCOVID

Enrollment

Registered

2020-04-14

Start date

2020-04-09

Completion date

2027-06-25

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chilblains, COVID, Skin Manifestations

Brief summary

Some patients infected by covid-19 develop skin manifestations. These manifestations are still not well known and there pathophysiology remain unclear. Among them, acral manifestation resembling to chilblains appears frequent and quite specific. The aim of this project is to better characterize the cutaneous manifestations occurring during Covid-19 infection with a special focus on chilblains. These acral manifestation could be due to a direct viral effect, but also to microthrombosis or vascularitis. Understanding the pathomechanisms involved could provide interesting clue for understanding not only the skin manifestations but also some of the other systemic symptoms associated to covid-19 infection. This study plan to characterize these acral manifestations by analyzing the clinical and dermoscopic patterns and to correlate them with the non-invasive vascular explorations but also immune and coagulopathy explorations that are done in the CHU of Nice in covid-19 patients.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 90 Years

Inclusion criteria

* All patients with proven covid infection (using PCR, serum antibody or lung TDM) and presenting at least one cutaneous lesions that occurred during the infection.

Design outcomes

Primary

Measure	Time frame	Description
Clinical skin manifestations	3 months	Type and description of the skin manifestations with a special focus on patients with chilblains

Secondary

Measure	Time frame	Description
Histology and biological data	3 months	Data on Histology (HE staining and immunofluorescence) and on biology (blood cells counts, CRP and immune profile) will be collected in covid patient with skin manifestation
Non invasive vascular examination	3 months	Vascular examination will be performed by Capillaroscopy, laser-doppler or lung TDM if clinically required

Countries

France

Contacts

CONTACTCynthia CAILLON

caillon.c@chu-nice.fr+33492034011

CONTACTSylvie MALERBA

malerba.s@chu-nice.fr+33492034011

Outcome results