Chalazion
Conditions
Keywords
microbiome/microbiota, probiotics, adults
Brief summary
There is growing evidence encouraging probiotics use in several diseases. The aim of the investigator's study is to define the possible beneficial impact of probiotics on adults suffering from chalazia.
Detailed description
Prospective comparative pilot study on 20 adults suffering from chalazion randomly divided into two groups. The first group, received conservative treatment with lid hygiene, warm compression, and dexamethasone/tobramycin ointment for at least 20 days. The second group, in addition to the conservative treatment, received a mixture of probiotic microorganisms once a day up to 3 months. Chalazia were classified according to their size into three groups: small (≤2 mm), medium (2-4 mm), or large (\>4 mm). When conservative treatment (with and without probiotics supplementation) failed to resolve the lesion, invasive methods were used, (intralesion steroid injection in medium size chalazion and surgical incision and curettage for the largest ones).
Interventions
OTHERconservative treatment
lid hygiene, warm compression, and dexamethasone/tobramycin ointment for at least 20 days.
DIETARY_SUPPLEMENTprobiotics
use specific probiotics in addiction to conservative treatment to modify the intestinal microbiome to ameliorate the clinical course of adults chalazia by re-establishing intestinal and immune homeostasis
Sponsors
University of Molise
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)
Intervention model description
Prospective comparative pilot study with two groups randomly divided
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* history of rapid onset of painful inflamed mass that had reached a stationary size for more than 2 months * clinical appearance and location of the lesion
Exclusion criteria
* eyelid infection * chalazion duration \< 1 month * nonpalpable chalazion * suspicion of malignancy * comorbidities (constitutional atopy and seborrheic dermatitis, hormonal dysfunction, presence of irritable bowel disease, infectious mainly related to Staphylococcus aureus and Propionibacterium acnes, demodex mite infestation, vitamin A deficiency, arterial hypertension, diabetes and pregnancy) * personal habits (smoking, eating disorders, etc.)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| healing time | 3 months | healing time changes with a complete resolution of chalazion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| recurrences | six months | evaluation of recurrences in both arms |
Countries
Italy
Outcome results
None listed