Congenital Cataract, Glaucoma
Conditions
Brief summary
To determine the incidence of glaucoma following bilateral congenital cataract removal and estimate the associated risk factors in a large cohort to provide guidance for clinical practice.
Detailed description
A prospective longitudinal cohort study of pediatric patients who underwent surgery for congenital/infantile cataracts between January 2011 and December 2025 was performed.
Interventions
None listed
Sponsors
Sun Yat-sen University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No
Inclusion criteria
* a diagnosis of bilateral congenital cataracts, the etiologies include congenital idiopathic cataract and congenital cataract associated with a systemic syndrome or ocular anomalies; * cataract surgery performed in ZOC; * age at cataract removal younger than 16 years;
Exclusion criteria
* the preoperative IOP was above 21 mm Hg; * family history of glaucoma; * signs of preoperative glaucoma were present, such as corneal clouding, corneal enlargement, excessive cup-disc ratio and myopic shift; * ocular trauma history; * previous surgery intervention and * they were noncompliant with our follow-up protocol to monitor the occurrence of glaucoma and glaucoma suspect.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the incidence of glaucoma after congenital cataract surgery | baseline | A Kaplan-Meier analysis was used |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Risk factors of glaucoma after congenital cataract surgery | baseline | Piecewise exponential survival models with mixed effects (PEWSMME) were used.(variables including demographic characters, surgery categories, clinical history, length of follow up). |
Countries
China
Outcome results
None listed