Coronavirus, COVID-19, Infection Viral
Conditions
Keywords
infection viral, biological risk factor, coronavirus, covid-19
Brief summary
There is no predictive tool for patients admitted to the emergency department with a suspicion of Covid-19 that will worsen secondarily and require a heavy lifting. In a context of saturation of the healthcare system by the pandemic at Covid-19,it is essential to identify specific, accessible prognostic markers via minimally invasive sampling with low risk of infection for personnel caregiver, for optimal allocation of resuscitation resources. This study proposes to evaluate the biological markers of routine care known to be associated with resuscitation admission in relation to hospitalization on conventional service for the prediction of worsening of patients admitted to the emergencies for Covid-19.
Interventions
None listed
Sponsors
University Hospital, Lille
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical criteria for suspicion of Covid-19 in an epidemic period * Consultation in the emergency departement * Non-opposition agree
Exclusion criteria
* impairment related to another identified cause than Covid-19, in particular a rapid diagnostic test flu-positive * Severe patient from the outset with transfer to intensive care within 12 hours of admission to the Emergency Department * No social security coverage (beneficiary or entitled person) * Poor understanding of French * Refusal to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of secondary aggravation | an average at 30 days (- 2 days +3 days) of admission to the emergency department | Secondary aggravation is defined as : * a re-hospitalization or * aggravation in hospitalization : development or increase in oxygen dependency, hemodynamic failure, and/or respiratory, death |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of standart biological parameters | Between baseline and an average at 30 days (- 2 days +3 days) of admission to the emergency department | the number of leukocytes, lymphocytes, neutrophil polynuclear cells, CRP, fibrinogen, and the D-dimers. |
| Change of Von willebrand factor (vWF) changes over time | Between baseline and an average at 30 days (- 2 days +3 days) of admission to the emergency department | — |
| Change of the Factor VIII (FVIII) | Between baseline and an average at 30 days (- 2 days +3 days) of admission to the emergency department | — |
| Prevalence of positivity of COVID-19 virus measured by PCR or serology | an average at 30 days (- 2 days +3 days) of admission to the emergency department | — |
Countries
France
Outcome results
None listed