Acute Stroke
Conditions
Keywords
tDCS, Acute Stroke, WMFT, SWMT, Fugl Meyer
Brief summary
40 acute subjects will be split into 5 groups. Each group will receive one of the following tDCS montages : anodal, bilateral, cathodal, extracephalic or placebo. Subjects will receive, in addition to conventional rehabilitation, 2mA for 20 mins of their attributed tDCS, 5 times a week. Evaluations will take place before the first stimulation period (48h post stroke), after 1, 2, 3 and 4 weeks. Evaluations consist of the Wolf Motor Function Test, the Fugl Meyer, and the Semmes Weinstein Monofilament Test
Detailed description
40 acute subjects will be randomized and split into 5 groups. Each group will receive one of the following tDCS montages : Anodal : Anode placer over the affected primary motor cortex, cathode over contralateral supra orbital area Bilateral : Anode placer over the affected primary motor cortex, cathode over unaffected motor cortex Cathodal : Cathode placer over the unaffected primary motor cortex, anode over contralateral supra orbital area Extracephalic : Anode placer over the affected primary motor cortex, cathode over right shoulder Placebo : anode montage but current is ramped up over 15 secondes, then ramped down. Subjects will receive, in addition to conventional rehabilitation (±1.5h/weekday), 2mA for 20 mins of their attributed tDCS, 5 times a week. Evaluations will take place before the first stimulation period (48h post stroke), after 1, 2, 3 and 4 weeks. Evaluations consist of the Wolf Motor Function Test, the Fugl Meyer, and the Semmes Weinstein Monofilament Test All researchers, therapists, data analysis and patients are blinded by a code system implemented in the tDCS machine
Interventions
DEVICETranscranial Direct Current Stimulation
Subjects received a micro-current through their scalp to induce cortical and subcortical changes
Sponsors
University of Liege
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Masking description
Everyone is blinded, codes are selected by a third party not involved in any step of the study
Intervention model description
5 groups, each group receives one of four treatments or the sham treatment. Double-blinded, sham controlled study
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* First Ever Stroke * Motor or sensory deficit * Understands and follows orders * Signed inform consent
Exclusion criteria
* One Yes on the medium and high risk sections of the TSST (Bornheim et al.,2019)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Wolf Motor Function Test | Pre Stimulation (48 hours post stroke), Week 1, Week 2, Week 3, Week 4 | Functional upper limb test, filmed and scored subjectively |
| Change in Fugl Meyer Motor Assessment | Pre Stimulation (48 hours post stroke), Week 1, Week 2, Week 3, Week 4 | Functional upper limb, lower limb and sensory test |
| Change in Semmes Weinstein Monofilament Test | Pre Stimulation (48 hours post stroke), Week 1, Week 2, Week 3, Week 4 | 11 Point Sensory test |
Countries
Belgium
Contacts
Primary ContactStephen Bornheim, Msc
Outcome results
None listed