Megacolon
Conditions
Keywords
Megacolon
Brief summary
The aim of this retrospective cohort study is to analyze all available data of patients with chronic megacolon in three clinical centers with respect of conservative and surgical therapies.
Detailed description
Megacolon may be defined as dilatation of the abdominal colon with a minimum of 9 cm in diameter and the absence of mechanical obstruction. Chronic megacolon in adults is an acquired uncommon condition that generally is associated with constipation. It has to be distinguished from other forms of megacolon such as acute toxic megacolon, acute non-toxic megacolon (Ogilvie´s-syndrome) and congenital megacolon (Hirschsprung disease). Regardless of concomitant diseases and causes, most patients with chronic megacolon were treated by laxative measures. Less is known about the optimal conservative therapy . If conservative measures fail, there are several surgical options, depending upon anorectal function. However, less in known about the optimal surgical therapy of patients with chronic megacolon. The aim of this retrospective cohort study is to analyze all available data of patients with chronic megacolon in three clinical centers with respect of conservative and surgical therapies.
Interventions
PROCEDUREcolon surgery
There are no guidelines to direct surgical therapy in patients with chronic megacolon. Historically, it is the surgeons individual choice to use one of the above mentioned surgical treatments. Therefore, the aim of this study is to analyze the success and downsides of the different surgical approaches.
DRUGLaxatives
There are no guidelines to direct laxative measures in patients with chronic megacolon. Historically, it is the gastroenterologists individual choice to use one of the above mentioned laxative measures. Therefore, the aim of this study is to analyze the success and downsides of the different Laxative measures.
Sponsors
Technical University of Munich
Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Chronic megacolon (colon diameter \> 90 mm)
Exclusion criteria
* Toxic megacolon * Ogilvie-syndrome * Hirschsprung disease * Mechanical colorectal obstruction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Constipation | One year after inpatient treatment (conservative/surgery) | Number of constipation crises leading to further hospital admissions: n |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hospital stay | Three months after inpatient treatment (conservative/surgery) | Hospital stay after inpatient treatment (conservative/surgery): days |
| Adverse events | 30 days after inpatient treatment (conservative/surgery) | Any adverse event after inpatient treatment (conservative/surgery): n |
Countries
Germany
Outcome results
None listed