Safety and Effectiveness of Low-flow ECMO Driving by CVVH Machine in Severe NCP

Safety and Effectiveness Study of Low Flow Extracorporeal Membrane Oxygenation（CO2 Removal） Driving by Continuous Hemofiltration Machine the Severe New Corovirus Pneumonia (NCP)

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04340414

Enrollment

Registered

2020-04-09

Start date

2020-02-20

Completion date

2020-10-15

Last updated

2020-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19, ECMO

Brief summary

assess the safety and effectiveness of using low-flow extracorporeal membrane oxygenation(CO2 removal) driving by CVVH machine in the severe NCP patients

Interventions

DEVICELow flow ECMO driving by CVVH machine

With aim to clear CO2 and improve oxygenation, a low flow ECMO treatment(using oxgyenator membrane of kid type ) driving by CVVH machine will be performed in the NCP with severe ARDS

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

14 Years to No maximum

Healthy volunteers

Inclusion criteria

* 1\. NCP with severe acute respiratory distress syndrome with ratio of partial pressure of arterial oxygen over fraction of inspired oxygen (PaO2:FiO2)\<150 and PEEP \>10cmH2O * 2\. Driving pressure\> 20cmH2O * 3\. RR\>30bpm * 4.PaCO2\>55cmH2O and/or PH\>7.3

Exclusion criteria

* 1\. poor venous vascular condition and unavaible for central venous catheter placement

Design outcomes

Primary

Measure	Time frame	Description
PaCO2	Day 1	PaCO2 from blood gas analysis
Driving Pressure	Day 1	Driving Pressure monitor by ventilator
Tidal volume	Day 1	Tidal volume monitor by ventilator

Countries

China

Contacts

Primary ContactYun Long, MD

ly_icu@aliyun.com+8610169152300

Backup ContactYun Long