Discovery of Biomarkers for Intrinsic Radiation Sensitivity in Cancer Patients

Conditions

Nasopharyngeal Cancer, Other Cancer, Prostate Cancer

Keywords

Radiotherapy, Biomarkers, Genomics, Immunomics, Precision medicine

Brief summary

Patients with cancers that are sensitive to radiotherapy treatment and/or patients who have experienced severe acute/ late side effects to radiotherapy will be recruited to the study. Blood and/or matched tumour-normal tissue pairs will be collected. Blood and/or tissue samples will be processed and studied for genetic and biochemical markers that have potential to be used for predicting sensitivity to radiation.

Boon Hao Hong, Enya Ong, Kah Min Tan, Jeffrey Tuan, Michael L.C. Wang et al. (12 authors)

Journal of Clinical Oncology2026-06-23

10.1200/jco.2026.44.19_suppl.196

Assessing the clinical and biological associations between multimodal artificial intelligence (MMAI) and 22-gene genomic classifier (GC) in localized prostate cancer (PCa).

Boon Hao Hong, Enya Ong, Kah Min Tan, Jeffrey Tuan, Michael L.C. Wang et al. (12 authors)

Journal of Clinical Oncology2026-05-27

10.1200/jco.2026.44.16_suppl.5114

Dynamic biological and metabolic response by EBV DNA and <sup>18</sup> F-FDG-PET-CT to induction chemotherapy (IC) to enhance prognostication in endemic nasopharyngeal carcinoma (NPC).

Jialing Neo, Enya Ong, Janice Ser Huey Tan, Wen Min Chow, Britny H.S. Koh et al. (15 authors)

Journal of Clinical Oncology2026-05-27

10.1200/jco.2026.44.16_suppl.6112

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

21 Years to 99 Years

Healthy volunteers

No

Inclusion criteria

* Patients with severe side effects from radiotherapy * Patients with a type of cancer that is associated with sensitivity to radiotherapy

Exclusion criteria

* Age of patient must be between 21 (inclusive) and 99 (exclusive)

Design outcomes

Primary

Measure	Time frame	Description
To identify genes or molecular pathways that are associated with radiation sensitivity in blood and tissue samples	Blood is taken at informed consent; tissue is from archived sample	Whole exome sequencing, single nucleotide polymorphism (SNP) assays
Change in immune profile of blood and tissue after radiation	Blood is taken at informed consent; tissue is from archived sample	Mass cytometry using CyTOF technology will be used to detect the immune cell population
To identify proteins that are associated with radiation sensitivity in tissue samples	Tissue is from archived sample	Immunohistochemistry will be used to detect protein expression
To identify RNA expression pathways that are associated with radiation sensitivity in blood and tissue samples	Blood is taken at informed consent; tissue is from archived sample	RNA sequencing

Countries

Singapore

Contacts

Primary ContactMelvin Chua, MD

melvin.chua.l.k@singhealth.com.sg

Backup ContactEnya Ong

enya.ong.h.w@nccs.com.sg+65 6436 8000

Outcome results