Liver Disease Chronic
Conditions
Keywords
Liver, Fecal, Gut microbiota
Brief summary
Gut microbiota modulation has effect on chronic liver disease
Detailed description
Chronic liver disease has been known as a disease of the liver which lasts over a period of 6-month. It consists of inflammation, hepatitis, cirrhosis, hepatocellular carcinoma. Gut microbiota plays an important roles in the chronic liver disease. It can suppress the progression of the liver disease by moulation gut microbiota. The investigators are still evaluating the effect of gut microbiota on the liver disease.
Interventions
OTHERDNA extraction
Extraction fecal DNA and compare disease group to normal group
Sponsors
Chuncheon Sacred Heart Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
31 Years to 82 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 19+ * Normal : AST or ALT level \< 50IU/L, BMI \< 25 * Liver disease : AST or ATL level ≥ 50IU/L, BMI ≥ 25 * Patients hospitalized with chronic liver disease (viral hepatitis, alcoholic liver disease, non-alcoholic liver disease, cirrhosis, liver cancer)
Exclusion criteria
* Normal : AST or ATL level ≥ 50IU/L, BMI ≥ 25 * Liver disease : AST or ALT level \< 50IU/L, BMI \< 25 * If the patient refuses
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fecal DNA | 10 years | Compare the species and proportions of the gut microbiome |
| Liver enzyme | 10 years | Compare the liver enzyme level |
| BMI | 10 years | Compare the body mass index |
Countries
South Korea
Outcome results
None listed