Post-operative Pain Reduction

Post-operative Pain Reduction After Application of Three Intracanal Medicament Within Necrotic Root Canals and Pulp

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04338633

Enrollment

Registered

2020-04-08

Start date

2020-04-30

Completion date

2020-11-30

Last updated

2020-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effects of the Elements

Brief summary

Recruited patients with necrotic pulp after application of conventional calcium hydroxide paste are assigned to group, Calcium hydroxide nanoparticle group and Combined Calcium hydroxide with silver nanoparticle group and record postoperative pain afterwards.

Detailed description

The investigator will recruit patients who are found eligible to the criteria, conventional calcium hydroxide paste , Calcium hydroxide nanoparticle and Combined Calcium hydroxide with silver nanoparticle . After 48 hours, patients will be randomly assigned to removal of intracanal medication After the visit, patients will be asked to record post operative pain by Numerical Rating Scale)in a given sheet

Interventions

DRUGConventional calcium hydroxide paste

Conventional calcium hydroxide paste (Ultracal) will be removed in second visit.

DRUGCalcium hydroxide nanoparticle

Calcium hydroxide nanoparticle. manufactured in NanoTech. institute, will be removed in second visit.

DRUGCombined Calcium hydroxide with silver nanoparticle

Combined Calcium hydroxide with silver nanoparticle will be removed in second visit.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Masking description

double

Eligibility

Sex/Gender

ALL

Age

25 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* • Medically free patients. * Patient's age between 25-50 years. * Sex includes both male and female. * Radiographic evidence of a periapical radiolucent lesion associated with tooth. * Necrotic pulp as indicated by thermal pulp testing. * No history of previous endodontic treatment of the tooth.

Exclusion criteria

* • Teeth with unfavorable conditions for rubber-dam application. * Teeth with acute periapical abscesses swelling. * Medically compromised patients. * Immature teeth with open apices. * Multi rooted teeth. * Pregnant women.

Design outcomes

Primary

Measure	Time frame	Description
change in post operative pain (Visual Analogue Scale)	Intrappointment at 4,24,48,72 and 96 hours ]	Numerical (0-10)

Countries

Egypt

Contacts

Primary ContactMohamed Salah Hegazi

mshegazi2006@gmail.com+201224014179

Backup ContactReham Hassan, Assoc Prof

reham-hassan@live.com+201001542529

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026