Heart Failure, Diastolic
Conditions
Brief summary
The study seeks to measure pulmonary transit time via contrast-echocardiography before and after exercise.
Detailed description
The ability to measure the amount of blood in the lungs using heart-ultrasound (echocardiography) can be useful to estimate how much fluid is in a patient's circulation, which can influence diagnosis and treatment of certain types of heart failure. In some patients, the amount of fluid is normal at rest, but can increase with activity and thus a diagnosis of heart failure can only be made after exercising. Currently, the amount of fluid is measured invasively. We have shown that echocardiography can measure the amount of fluid in the lung circulation at rest without the need for an invasive procedure. We now seek to find out if we can make a similar measurement after exercise. If successful, the need for catheter procedures may be reduced in certain types of heart failure.
Interventions
DIAGNOSTIC_TESTcontrast echocardiography
giving echocardiographic contrast and taking echocardiographic images before and after exercise
Sponsors
Vanderbilt University Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
small pilot study to test technical feasibility
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Age ≥ 18 years old 2. Able to give informed consent
Exclusion criteria
1. Known allergic reaction to Definity or Optison ultrasound contrast 2. Pregnancy/Nursing - as assessed/disclosed by the participant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pulmonary Transit Time | 3-10 seconds | interval required for the pulmonary blood volume to traverse the pulmonary circulation |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Exercise Everyone is in this arm
contrast echocardiography: giving echocardiographic contrast and taking echocardiographic images before and after exercise | 14 |
| Total | 14 |
Baseline characteristics
| Characteristic | Exercise |
|---|---|
| Age, Continuous | 46 years STANDARD_DEVIATION 8 |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants |
| Race (NIH/OMB) Asian | 1 Participants |
| Race (NIH/OMB) Black or African American | 0 Participants |
| Race (NIH/OMB) More than one race | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) White | 13 Participants |
| Region of Enrollment United States | 14 participants |
| Sex: Female, Male Female | 2 Participants |
| Sex: Female, Male Male | 12 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 0 / 14 |
| other Total, other adverse events | 0 / 14 |
| serious Total, serious adverse events | 0 / 14 |
Outcome results
Primary
Pulmonary Transit Time
interval required for the pulmonary blood volume to traverse the pulmonary circulation
Time frame: 3-10 seconds
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Exercise | Pulmonary Transit Time | 2.5 seconds | Standard Deviation 0.5 |