Papillary Thyroid Carcinoma
Conditions
Keywords
papillary carcinoma, recurrence of PTC, Radio-iodine therapy for PTC
Brief summary
study assigned into three groups, Group I was the control group operated by total thyroidectomy and retrospectively followed, where the other two groups Operated by Total thyroidectomy and central neck dissection. Recurrence Free Survival (RFS) was the main issue of the study and calculated as the time from date of surgery to date of relapse or the most recent follow-up contact that patient was known as relapse-free, Study exclusively studied the outcome and advantage of central neck dissection
Detailed description
informed consent taken, study was a prospective cohort study, with controlled group a retrospectively. patients ablated by total thyroidectomy only who failed to achieve ablation with the first dose of iodine 131I may be dynamically risk stratified as high-risk category and managed aggressively. N0 patients will benefit and ablated by total thyroidectomy and prophylactic central neck dissection, PCND decreases the residual, increase the RFS and patients without residual do not need adjuvant RAI therapy except in high risk group. Histological grading, size of the primary tumour, the extension of PTC, the extent of surgery were found to be a strong predicting factor for recurrence-free survival Locoregional recurrence cases always found more in male patients aged more than 45 years old. Size of the primary tumour and the extent of surgery was a significant factor for RFS,
Interventions
Sponsors
Study design
Masking description
guuartor of study, only participant
Intervention model description
prospective cohort study
Eligibility
Inclusion criteria
* Age ≥20 years, Histopathology proved PTC, with no lymph nodes detected (N0)
Exclusion criteria
* Younger age ≤20 years. Prior thyroidectomy, previous radiation exposure, postoperative radioactive iodine therapy, Histopathology report of any type of malignancy other than PTC or patients did not complete their postoperative follow-up period. PTC With N1 or N2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| recurrence free survival | 21 months | recurrence free survival calculated from first day of diagnosis |
Countries
Egypt