Oral Lichen Planus
Conditions
Keywords
matrix metalloproteinase inhibitors, orochem, OLP
Brief summary
The current study will be conducted to evaluate the effectiveness of matrix metalloproteinases inhibitors on erosive oral lichen planus.
Detailed description
Matrix metalloproteinases inhibitor (Orochem) will be given to patients with Oral erosive lichen planus three times daily for 3 weeks. Then the subjective discomfort and pain severity as well as the objective disease severity scores will be collected.
Interventions
DRUGMatrix Metalloproteinase Inhibitors (Orochem)
topical application of MMP inhibitors for 3 weeks to evaluate its effectiveness in treating oral lichen planus
DRUGKenacort A,
topical application of both drugs 3 times daily for 3 weeks as an active control
Sponsors
Jaylane kadry Ghonima
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
participant, investigator as well as outcome assessor are blinded
Intervention model description
double equal arms
Eligibility
Sex/Gender
ALL
Age
25 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients diagnosed with erosive OLP confirmed with a biopsy. * patients should have symptomatic lesions
Exclusion criteria
* Patients who were under anticoagulant medications, suffering from any systemic diseases or having any physical or mental abnormality, pregnant and lactating women, smokers.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in disease severity score | change in disease severity score from baseline to 3 weeks | Thongprasom disease severity score (5-0) |
Countries
Egypt
Outcome results
None listed