COVID, Fatigue Post Viral, Pediatric Respiratory Diseases
Conditions
Brief summary
Prospective cohort study of COVID-19 infection among children in Norway.
Detailed description
This nation-wide, prospective cohort study of COVID-19 infection addresses three main issues: 1) Epidemiological risk factors; 2) Natural history (including immunological mechanisms and long term effects) and 3) Support of infection prevention. Also, the study focuses solely on children. Children (0-18 years of age) admitted to hospital with suspected COVID-19 are eligible (Fig. 1). Those with confirmed COVID-19 serve as cases, whereas those with non-COVID-19 serve as controls; both groups will be followed prospectively for 6 months. Three objectives/Work Packages (WPs) are defined: * In WP1, the investigators will investigate risk factors for severe outcome of the acute infection; potential risk factors include sex, age, comorbidities, initial clinical findings, infectious load, and genetic markers. * In WP2, the investigators will investigate the immunological response to acute infection, focusing on initial innate host response and its associations to inflammatory enhancement, genetic factors and clinical course. * In WP3, the investigators will investigate the prevalence and risk factors of long-lasting complication, in particular the development of post-infectious chronic fatigue
Interventions
None listed
Sponsors
St. Olavs Hospital
Helse Stavanger HF
Haukeland University Hospital
University Hospital of North Norway
Alesund Hospital
Norwegian Institute of Public Health
The University of New South Wales
University of Bristol
Sykehuset Ostfold
Nordlandssykehuset HF
Vestre Viken Hospital Trust
Helse Fonna
Helse Nord-Trøndelag HF
Oslo University Hospital
Sykehuset Innlandet HF
University Hospital, Akershus
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No
Inclusion criteria
Suspected covid-19 infection and age 0-18 years
Exclusion criteria
Age \>18 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Risk Factors for severe infection | 2030 | Identify comorbidities predisposing for severe infection |
| Immunulogical mechanisms | 2030 | Immunological response to acute infection, focusing on initial innate host response and its associations to inflammatory enhancement, genetic factors and clinical course. |
| Long term outcome | 2030 | prevalence and risk factors of long-lasting complication, in particular the development of post-infectious chronic fatigue |
Countries
Norway
Contacts
Primary ContactChristopher Inchley, Phd
Backup ContactLise Beier Havdal
Outcome results
None listed