Obesity, Overweight
Conditions
Keywords
Non-nutritive sweeteners, postprandial glucose, diabetes, obesity, satiety
Brief summary
This study aims to assess the effect of stevia extract on postprandial glucose and insulin levels in overweight and obese adults when compared to sugar and water.
Detailed description
The study is a three-arm crossover trial involving participants attending the Lab on 3 different occasions (separated by 3-5 day washout period), where they will be administered water, sugar solution (65g), water and stevia extract (5g) solution. The solution will be followed by a consumption of a fixed meal (after 30 minutes). Breakfast will be standardised. Capillary blood glucose will be collected every 30 min until 2 hours post meal. Venous blood samples will be collected before the intake of the solution and at 2 hours after meal intake.
Interventions
OTHERsugar replacements
Participants will receive a solution of stevia before being administered a fixed meal (lunch). Glucose and insulin levels, and Visual analogue scale data will be collected.
Sponsors
Liverpool Hope University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Masking description
Single (participant)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-65 years * BMI 27-40 Kg/m2 * Males and females
Exclusion criteria
* Athletes * Pregnant or breastfeeding women * Patients with chronic disease (diabetes, CVD etc…).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postprandial glucose levels | Capillary blood glucose will be measured two hours after the administration of a fixed meal. | Change in glucose levels two hours after the administration of a fixed meal |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postprandial insulin levels | Postprandial insulin levels will be measured two hours of the administration of a fixed meal | Change in postprandial insulin levels two hours after the administration of a fixed meal |
| Area under the curve (AUC) for glucose | Capillary blood glucose levels will be collected 6 times on each visit before the intake of the solution until 2 hours post lunch | Changes in AUC for glucose throughout the intervention |
| Subjective feelings of satiety | VAS will be collected 6 times on each visit before the intake of the solution until 2 hours post lunch. | Visual analogue scales |
Countries
United Kingdom
Outcome results
None listed