Obsessive-Compulsive Disorder, Sensory Disorders, Tourette Syndrome
Conditions
Keywords
sensory dysregulation, sensory gating dysfunction, tic, obsessive compulsive, sensory symptom
Brief summary
This study seeks to address two key questions related to sensory dysregulation in Tourette syndrome (TS) and obsessive compulsive disorder (OCD): 1) Is sensory dysregulation in OCD clinically distinct from that in TS? 2) To what extent does sensory dysregulation affect QOL in each of these disorders? Patients with TS, patients with OCD, and healthy controls will complete an online battery of validated questionnaires assessing sensory dysregulation, psychiatric symptoms, and quality of life.
Detailed description
Tourette syndrome (TS) is a neurodevelopmental disorder affecting 1% of school-aged children, with one-third of patients suffering persistent tics into adulthood. Obsessive-compulsive disorder (OCD) is a common comorbidity with TS. Individuals with either TS or OCD frequently exhibit sensory dysregulation, manifesting as heightened awareness of internal and external stimuli. For patients with OCD, sensory dysregulation has been linked to obsessive-compulsive symptoms and is an important consideration in treatment strategies. Sensory dysregulation remains largely unexplored in TS, but preliminary data suggests it is dissociable from tics, linked with obsessive-compulsive symptoms, and associated with poorer quality of life (QOL). This study seeks to address two key questions related to sensory dysregulation in TS and OCD: 1) Is sensory dysregulation in OCD clinically distinct from that in TS? 2) To what extent does sensory dysregulation affect QOL in each of these disorders? To do so, we will recruit patients with TS, patients with OCD, and healthy controls to complete an online battery of validated questionnaires assessing sensory dysregulation, psychiatric symptoms, and QOL. Addressing these knowledge gaps will enhance our understanding of bothersome sensory symptoms in TS and OCD, shed light on clinical overlap and/or distinctions between these commonly co-occurring psychiatric diagnoses, and clarify QOL impact and the potential need for more direct targeting of these symptoms.
Interventions
None - observational study
Sponsors
Vanderbilt University Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
for the patient groups: * age 18 years or older * previous diagnosis of Tourette syndrome and/or obsessive compulsive disorder
Exclusion criteria
for the patient groups: \- none Inclusion criteria for healthy controls includes: \- 18 years of age or older
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensory Gating Inventory | Day 1 | 36-item, validated self-report questionnaire assessing sensory gating symptoms, with score range 0-216. Higher scores indicate greater sensory gating impairment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Adult Attention Deficit Hyperactivity Disorder Self-Report Screening Scale | Day 1 | 6-item, validated self-report questionnaire assessing inattention and hyperactivity symptoms, with raw score range from 0-24. Higher scores indicate greater ADHD symptoms. |
| Generalized Anxiety Disorder-7 Scale | Day 1 | 7-item, validated self-report questionnaire assessing anxiety symptoms, with score range from 0-21. Higher scores indicate more severe anxiety. |
| Patient Health Questionnaire-9 Scale | Day 1 | 9-item, validated self-report questionnaire assessing depression symptoms, with score range from 0-27. Higher scores indicate more severe depression. |
| Dimensional Obsessive Compulsive Scale | Day 1 | 20-item, validated self-report questionnaire assessing obsessive compulsive symptoms, with score range 0-80. Higher scores indicate more severe obsessive compulsive symptoms. |
| Adult Tic Questionnaire (for Tourette syndrome patients only) | Day 1 | 27-item, validated self-report questionnaire assessing frequency and severity of tics, with score range from 54-216. Higher scores indicate greater tic burden. |
| WHO Quality of Life - BREF | Day 1 | 26-item, validated self-report questionnaire assessing 4 domains of health: physical, psychological, social, and environmental. 54-216. Higher scores indicate greater tic burden. Scores range from 0-100 within each domain. Higher scores indicate better quality of life. |
| Premonitory Urge to Tic Scale (for Tourette syndrome patients only) | Day 1 | 10-item, validated self-report questionnaire assessing premonitory urge symptoms, with score range from 9-36. Higher scores indicate more severe premonitory urge prior to tics. |
Countries
United States
Outcome results
None listed