A Retrospective Cohort Study Outcome of Treatment in Asymptomatic Stage 4 Colorectal Cancer

A Retrospective Cohort Study Outcome of Treatment in Asymptomatic Stage 4 Colorectal Cancer : Primary Tumor Resection vs. No Primary Tumor Resection

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04334395

Enrollment

135

Registered

2020-04-06

Start date

2017-01-01

Completion date

2020-03-31

Last updated

2020-04-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stage IV Colon Cancer

Brief summary

In asymptomatic Stage 4 colorectal cancer, the treatment varies between many hospitals and countries. Some studies found that primary tumor resection had better survival rates and a lower risk of mortality. But many studies found significant benefits in survival in sub groups of the population such as age less than 70 years, WHO performance status \<2, no extra-hepatic metastasis, liver tumor burden \<50%. However some studies showed no survival benefits in primary tumor resection. So this study will focus on survival, adverse events, complications in primary tumor resection and no primary tumor resection in asymptomatic Stage 4 colorectal cancer.

Detailed description

The retrospective study of patients in asymptomatic Stage 4 colorectal cancer received treatment at Ramathibodi Hospital and excluded symptomatic primary tumors such as obstruction, perforation that required surgery, carcinomatosis peritoneii, and patients with secondary cancer diagnosis in the past 5 years.

Interventions

PROCEDUREprimary tumor resection group

resection of cancer at colon

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Asymptomatic stage IV colorectal cancer * pathological prove adenocarcinoma * age \>18 years * no primary tumor related symptom * ECOG performance status \<2

Exclusion criteria

* symptomatic primary tumor such as obstruction , perforation that required surgery * carcinomatosis peritoneii * patients with secondary cancer diagnosis in 5 years

Design outcomes

Primary

Measure	Time frame	Description
Complication rate	5 year	The definition of complication defined as symptom that occurred during treatment period such as obstruction , perforation , bleeding , trenesmus.

Secondary

Measure	Time frame	Description
The survival time	5 year	The survival time defined as time from diagnosis to death or last follow up period

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026