Multi Point Pacing vs. Conventional STUDY PROTOCOL

Observational, Multicentre, Investigator and Patient Blinded, Prospective, Randomized Comparator Study of Cardiac Resynchronization Therapy (CRT) Multi Point Pacing (MPP) Compared to Conventional CRT Pacing Response in Heart Failure Patients.

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04334018

Acronym

CRT-MPP

Enrollment

Registered

2020-04-03

Start date

2018-03-01

Completion date

2023-03-01

Last updated

2020-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Compare Two Programming Modalities for CRT Devices in Heart Failure Patients With an Indication for Cardiac Resynchronization Therapy

Brief summary

The Purpose of this study is to compare two programming modalities for CRT devices in Heart Failure patients with an indication for Cardiac Resynchronization Therapy

Interventions

DEVICEconventional CRT

Conventional CRT or biventricular pacing resynchronizes left ventricular contraction by pacing the right and left ventricles (LV) simultaneously

DEVICEMPP CRT

CRT with Multipoint pacing (MPP) where pacing can occur from more than one LV site simultaneously

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

OTHER

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with indication for CRT (-P or -D) as per ESC guidelines. Ability to provide written informed consent. Optimal Medical Therapy for at least 3 months

Exclusion criteria

* \< 18 years and younger * Pregnant or breastfeeding patients * Non-LBBB patients (RBBB, intra-ventricular delay) * Non-ambulatory NYHA class IV effort tolerance * Myocardial infarction within 40 days before enrolment * Cardiac surgery or revascularization procedure within 3 months before enrolment, or scheduled in the following 6 months * Atrial Fibrillation (AF) patients unless AV node ablation is performed, or complete AV block is present (to ensure optimal CRT delivery) * Patients with life expectancy of less than 12 months due to other medical conditions * Patients who are involved in another investigational study (device or medical)

Design outcomes

Primary

Measure	Time frame	Description
Outcome 1	12 months	To evaluate the clinical improvement of CRT MPP as compared to conventional CRT in Heart Failure patients with indication for CRT using automated intra-cardiac EGMs analysis (QuickOpt™) for device optimization, in a large multicentre international study.

Countries

France, Monaco

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026