Refractory Status Epilepticus, Status Epilepticus
Conditions
Keywords
artificial deep coma, intravenous anesthetic drugs (IVADs), total seizure oppression
Brief summary
This study is to investigate the effects of different treatment characteristics regarding the use of intravenous anesthetic drugs (IVADs) as a rescue treatment for refractory Status epilepticus (RSE) on course and outcome. A retrospective data extraction from the digital medical records, the electroencephalographic and microbiologic database of all consecutive adult patients with Status epilepticus (SE) admitted to the University Hospital Basel is undertaken.
Interventions
OTHERData collection
collection of patient data Data collection (demographics, prehospital management, duration of ICU and hospital stay, destination at discharge, date(s) of seizure(s), electroencephalographic (EEG) data, seizure history and etiology, number and duration of SE episodes, medication, types of SE according to the current guidelines from the International League of Epilepsy (ILAE), neuroimaging features, comorbidities, laboratory parameters, complications during and after SE , laboratory testing, vital signs, fluid balance) will be performed from the digital medical records, the electroencephalographic and microbiologic database of patients
Sponsors
University Hospital, Basel, Switzerland
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* diagnosed SE between 2005 and 2019 who have been treated at intensive care units (ICUs) of the University Hospital of Basel
Exclusion criteria
* Patients with repetitive epileptic seizures not qualifying for SE or RSE * Patients with documented refusal of the general in-house consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| number of in- hospital death | at baseline (T0) | number of in- hospital death |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| neurofunctional alteration assessed by Glasgow Outcome Score (GOS) | at baseline (T0) | neurofunctional alteration assessed by Glasgow Outcome Score (GOS). The Glasgow Outcome Scale (GOS) is a global scale for functional outcome that rates patient status into one of five categories: Dead, Vegetative State, Severe Disability, Moderate Disability or Good Recovery |
Countries
Switzerland
Outcome results
None listed