Periostin and Non-Surgical Periodontal Treatment

The Effect of Non-Surgical Periodontal Treatment on Gingival Crevicular Fluid Periostin Levels in Patients With Gingivitis and Chronic Periodontitis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04332965

Enrollment

Registered

2020-04-03

Start date

2017-01-31

Completion date

2018-04-30

Last updated

2020-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal Diseases

Keywords

Chronic periodontitis, Gingival crevicular fluid, Gingivitis, Non-surgical periodontal treatment, Periostin

Brief summary

A total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. Patients with periodontal disease received non-surgical periodontal treatment. Gingival crevicular fluid periostin levels were assessed at baseline, at the 6th week and the 3rd month after treatment.

Detailed description

Periostin is commonly found in collagen-rich tissues, which is thought to affect the production of collagen fibers. Additionally, periostin is synthesized in tissues exposed to constant mechanical forces such as the periosteum, periodontal ligament, tendon, heart valve and skin. Periostin mediates inflammation and fibrosis during diseases of various organs, including the heart, lung, kidney, skin, liver, skeletal muscle and retina. This study evaluated periostin levels in gingival crevicular fluid from patients with chronic periodontitis, gingivitis and periodontally healthy as well as the effect of non-surgical periodontal treatment on gingival crevicular fluid periostin levels.

Interventions

PROCEDURENon-Surgical Periodontal Treatment

Scaling and root planing and polishing with specific curettes were performed to patients and oral hygiene education was provided to each patient.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Clinical diagnosis of chronic periodontitis * Clinical diagnosis of gingivitis * Clinical diagnosis of periodontal health

Exclusion criteria

* have any systemic disease * to be alcohol consumer * to receive any periodontal therapy in the past 6 months * to take any drugs regularly * to be pregnant and/or lactate

Design outcomes

Primary

Measure	Time frame	Description
Change in periostin	Baseline, 6th week and 3rd month	Total amount of Periostin (pg/30 sec) in gingival crevicular fluid

Secondary

Measure	Time frame	Description
Change in periodontal clinical parameter	Baseline, 6th week and 3rd month	Clinical attachment level (mm) (from cemento-enamel junction to the base of periodontal pocket)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026