Damage and Renal Clearance of Glycocalyx in Cardiac Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04332952

Acronym

GlycoCarSur

Enrollment

Registered

2020-04-03

Start date

2017-08-01

Completion date

2017-12-31

Last updated

2020-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardio-Renal Syndrome, Glycocalyx

Keywords

Renal clearance, Glycocalyx, Cardiac surgery

Brief summary

The glycocalyx is a component of the vascular endothelium that currently plays a relevant role in the modified Starling theory. The manipulation of the heart during cardiac surgery stimulates the release of the natriuretic atrial peptide, which causes endothelial wear in patients undergoing extracorporeal circulation. Dilation of the atrium produces natriuretic atrial peptide, which reduces plasma volume by increasing renal excretion and vascular permeability. The atrial peptide degrades the surface of the coronary endothelium, causing loss of the side cam protein nucleus. This study investigates the relationship between clamping time in cardiac surgery and the clearance of endothelial inflammation markers.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Over 18 years of age * Patients who underwent cardiac surgery for a single valve change or replacement

Exclusion criteria

* Stage 3 renal failure patients * Patients with a previous diagnosis of hematological malignancy * Patients undergoing pulmonary valve change surgery. * Patients undergoing Bentall and Bono surgery. * Patients Undergoing Coronary Artery Bypass Surgery

Design outcomes

Primary

Measure	Time frame	Description
Sydecan -1 levels in urine before surgery	30 minutes	Quantity of Sydecan -1 in urine before surgery
Sydecan -1 levels in urine after surgery	30 minutes	Quantity of Sydecan -1 in urine after surgery
Extracorporeal circulation time	2 hours	Duration of Extracorporeal Circulation in minutes
Aortic clamping time	2 hours	Duration of aortic clamping time in minutes
Hyaluronic acid levels in blood before surgery	30 minutes	Quantity of hyaluronic acid in blood before surgery
Hyaluronic acid levels in blood after surgery	30 minutes	Quantity of hyaluronic acid in blood after surgery
Hyaluronic acid levels in urine before surgery	30 minutes	Quantity of hyaluronic acid in urine before surgery
Hyaluronic acid levels in urine after surgery	30 minutes	Quantity of hyaluronic acid in urine before surgery
Sydecan -1 levels in blood before surgery	30 minutes	Quantity of Sydecan -1 in blood before surgery
Sydecan -1 levels in blood after surgery	30 minutes	Quantity of Sydecan -1 in blood after surgery

Countries

Mexico

Outcome results