Patents With Normal VQ/SPECT
Conditions
Brief summary
Ventilation - perfusion SPECT is attractive for lung function assessement. Unfortunately, it is very difficult to delineate normal to abnormal areas because of physiological uptake heterogeneity. In that context, it would be of interest to build statistical maps from registrered normal studies and propose a new methodology for normal SPECT delineation
Detailed description
Patients with normal VQ SPECT-CT will be analysed. After a image proccesing workflow including rigid registration, non rigid registration and normalization, a voxelized mean and standard deviation map will be created. Those maps will be analyzed in regards of physiology and litterature.
Interventions
None listed
Sponsors
University Hospital, Brest
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* normal perfusion and ventilation scans, and no parenchyma or pleural abnormality on low dose CT * confirmation by a second senior physician
Exclusion criteria
Patients with history of pulmonary disease: * chronic obstruction pulmonary disease, * previous pulmonary embolism, * surgery of the lungs * radiotherapy of the lungs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Posterior to Anterior and Inferior to Superior uptake relative difference on parametric mean registered SPECT map versus non registered SPECT | through study completion, an average of 3 months | parametric mean and standard deviation maps are build from elastic registration of normal lung V/Q SPECT-CT. A ROI based quantitative regional uptake comparison is performed to verify the influence of elastic registration on radiotracer distribution |
Countries
France
Outcome results
None listed