Obesity, Childhood
Conditions
Brief summary
The objective of this study is to estimate the proportion of the recurrent deletion Δ6-8 of the LEPR gene in the homozygous and heterozygous state in pediatric cases with severe and early ( before the age of 6) obesity (BMI ≥ IOTF-30) on Reunion Island.
Detailed description
The study of the deletion Δ6-8 of the LEPR gene starts with a saliva sample using a swab in children aged between 3 to 18 years old. The DNA from this sample will then be analyzed by the PCR technique. If the deletion of the LEPR gene is confirmed in the patient, his adult family members will also be screened using the same procedure.
Interventions
None listed
Sponsors
Centre Hospitalier Universitaire de la Réunion
Study design
Observational model
FAMILY_BASED
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* patient with early severe and non syndromic obesity (BMI\> IOTC-30) (before 6 years old) * adult family members with deletion of LEPR gene * informed consent form signed by participants or parents * affiliation to social security scheme
Exclusion criteria
* patient with syndromic obesity * patient Under guardianship or Under judicial protection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of the Δ6-8 deletion of the LEPR gene in paediatric population | at inclusion | Presence of the deletion of the LEPR gene |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of the Δ6-8 deletion of the LEPR gene in adult family members | 6 months after inclusion of the paediatric population | Presence of the deletion of the LEPR gene |
Contacts
Primary ContactEmilie TECHER
Outcome results
None listed