Carotid Endarterectomy, Carotid Stenosis
Conditions
Brief summary
Establish and validate biomarkers which improve the predictive value of current risk stratification models for patients benefiting from carotid revascularization, outperform existing biomarkers, and reach clinical application standards.
Detailed description
The authors hypothesize FGF-23 and GDF-15 could predict cerebral ischemia, postoperative complications and long term major cardiovascular events, particularly in patients developing symptomatic neurologic ischemia after circulation shutdown. Establish and validate biomarkers which improve the predictive value of current risk stratification models for patients benefiting from carotid revascularization, outperform existing biomarkers, and reach clinical application standards. Clarify the pathophysiology of carotid endarterectomy-related stroke and the role of GDF-15, FGF-23, BNP and hs-troponin I and other biomarkers in the prognosis of symptomatic carotid stenosis. Imagiologic markers are to be included - intima-media; gray weale plaque classification, cerebral CT Peak wave velocity
Interventions
DIAGNOSTIC_TESTBiomarker - FGF 23; troponin I; PCR - high sensitivity; BNP
peak wave velocity; gray weale plaque classification
Sponsors
Universidade do Porto
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Inclusion criteria
\- consecutive patients from a tertiary referral center who undergo CEA for carotid artery stenosis (CS) under regional anesthesia
Exclusion criteria
* general anesthesia * carotid stenting
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Stroke | 30 days, long-term | — |
| Clavien dindo>3 | 30 days, long-term | — |
| MACE | 30 days, long-term | AMI, stroke, Major adverse limb event, acute hear faillure hospitalization, all cause mortality |
Countries
Portugal
Contacts
Primary ContactJoao R Neves, MD, MSC; MPH
Outcome results
None listed