The Influence of NPPA/NPPB Haplotype on Natriuretic Peptide Plasma Levels

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04327258

Enrollment

437

Registered

2020-03-31

Start date

2011-01-31

Completion date

2014-12-31

Last updated

2020-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Surgical Procedure, Operative

Keywords

genetic association study

Brief summary

Crosssectional study to analyse the genetic influence on levels of cardiac biomarkers (BNP, NT-proBNP).

Detailed description

Background Natriuretic peptides play an important role in risk stratification and management of patients undergoing non-cardiac surgery. However, due to genetic variability, the levels of these biomarkers may differ in individual patients with cardiac derangement. In the preoperative setting, genetic contribution to natriuretic peptide plasma level variability has not yet been determined. Objective The aim of this study is to assess genetic contribution to NP plasma level variability in a Swiss cohort. Methods Cross-sectional association study in a cohort of non-cardiac surgery patients. This study is a Subproject of a prospective cohort study registered under the ID 041/09.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* 18 years and older * Written informed consent * Scheduled surgery

Exclusion criteria

* No informed consent * Cognitive impairment

Design outcomes

Primary

Measure	Time frame	Description
Influence of NPPA/NPPB haplotype on natriuretic peptide plasma levels	Blood samples collected at start of anesthetic procedure	Estimation of genetic effects on natriuretic peptide (BNP, NT-proBNP) plasma levels

Countries

Switzerland

Outcome results