Emphysematous Pyelonephritis
Conditions
Keywords
emphysematous pyelonephritis, intensive care unit, mortality, risk factors
Brief summary
Emphysematous pyelonephritis is a lifethreatening necrotizing infection of the kidney characterized by accumulation of gas in the renal parenchyma and within the surrounding tissues. The aim of the study is to report the outcome of the management of this condition at the investigators institution and to determine the microbiological characteristics, antibiotic resistance patterns, and to analyze factors predicting mortality and intensive care unit admission.
Detailed description
The investigators are planning to perform a retrospective study analyzing cases of emphysematous pyelonephritis from a single tertiary care institution in the north of Mexico in the period of 2011-2021. The diagnosis of emphysematous pyelonephritis is confirmed by computed tomography. Demographic, clinical, biochemical, therapeutic management, and outcomes will be collected. Variables will be analyzed to determine factors associated with admission to intensive care unit and mortality. Urine cultures will be analyzed and drug resistance profile will be determined using microdilution plate. Clinical and demographic characteristics will be analyzed using Chi square test for categorical variables, and T-test for numerical variables. Statistical significance is set at p\<0.05. Statistical analysis will be performed with the SPSS software version 20.0.
Interventions
PROCEDURENephrectomy
Different therapeutic options are described in literature for emphysematous pyelonephritis. In our center, medical treatment (no invasive procedure), ureteral stent (endourologic procedure), percutaneous drainage (minimally invasive procedure), and nephrectomy are the therapeutic options for this disease.
Sponsors
Hospital Universitario Dr. Jose E. Gonzalez
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Emphysematous pyelonephritis confirmed with computed tomography * Systemic inflammatory response * Urinary tract infection symptoms * Complete medical records * Both genders included * \>18 years old
Exclusion criteria
* Other infectious causes * Asymptomatic bacteriuria * Incomplete medical records * Endourologic procedure 3 months before recruitment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients with admission to Intensive care unit | 10 years | Patients with criteria to admit to intensive care unit |
| Rate of mortality | 10 years | Death cases during hospitalization |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Antibiotic susceptibility | 10 years | Drug resistance profile will be determined using microdilution plate. |
Countries
Mexico
Contacts
Primary ContactJose I Robles-Torres, M.D.
Backup ContactMarco A Ocaña-Munguía, M.D.
Outcome results
None listed