Influence of Intra-Canal Cryotherapy on Post-Endodontic Pain and Interleukin-6 Expression Using Different Irrigation Protocols: A Randomized Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04324398

Enrollment

Registered

2020-03-27

Start date

2017-12-01

Completion date

2018-10-09

Last updated

2020-03-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Symptomatic Periapical Periodontitis

Keywords

Cryotherapy, Interleukins, Postoperative pain, Sodium hypochlorite

Brief summary

the study was to evaluate the effect of intra-canal cryotherapy on post-endodontic pain and interleukin-6 expression in teeth with symptomatic apical periodontitis using different irrigation protocols.

Interventions

OTHERCryotherapy

cold application

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Anterior or premolar single canal in single rooted teeth. * Patients aged 20 to 50 years.

Exclusion criteria

* Patients under anti-inflammatory medication, immune-suppressive chemotherapy or any antibiotic medication for the last 2 months. * Pregnant or lactating females. * Teeth with endo-perio lesions.

Design outcomes

Primary

Measure	Time frame	Description
PAIN	one week	post-operative pain is measured by using visual analogue scale (VAS) The modified VAS will include a 10 cm straight horizontal line numbered at each centimeter with following criteria: (0) for no pain, (1-3) for mild pain, (4-6) for moderate pain, (7-9) for severe tolerable pain and (10) for severe intolerable pain

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026