Fetal Growth Retardation
Conditions
Brief summary
Need statement \- a new way to distinguish between a healthy small fetus and a small fetus suffering from deprivation of nutrition and oxygen to prevent unnecessary induction of preterm birth and improve neonatal outcome. Aim - to characterize fetal heart rate variability (fHRV) based on fetal ECG in the normal fetus and in the fetus suffering from growth retardation to evaluate its value and applicability as a supplementary tool in fetal surveillance. Aim of current study \- To evaluate the feasibility of NI-FECG from gestational week 20 and onwards and investigate if important factors as length and heart rate pattern affects repeatability of time domain and spectral analyses in fetuses.
Interventions
DIAGNOSTIC_TESTfetal heart rate variability
No direct intervention, as the study is observational.
Sponsors
Aarhus University Hospital
Snedkermester Sophus Jacobsen and hustru Astrid Jacobsens Foundation
Hartmann Fonden
Augustinus Fonden
The Dagmar Marshall Foundation
AP Moeller Foundation
Aalborg University
University of Aarhus
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
Yes
Inclusion criteria
• Healthy singleton pregnancies
Exclusion criteria
• Fetal malformations, multiple pregnancy, obstetric complications, maternal chronic disease and labor.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Standard deviation of normal to normal RR-interval (SDNN) | 01.04.2020 | Time domain analysis, measured in ms |
| Root mean square of successive RR-interval differences (RMSSD) | 01.04.2020 | Time domain analysis, measured in ms |
| Low frequency power (LF-power) | 01.04.2020 | Spectral analysis, measured in ms\^2 |
| High frequency power (HF-power) | 01.04.2020 | Spectral analysis, measured in ms\^2 |
| LF-power/HF-power | 01.04.2020 | Spectral analysis, ratio |
Countries
Denmark
Outcome results
None listed