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The Effect of Progesterone on Human Endometrium

The Effect of Progesterone Levels on Human Endometrial Transcriptomics During the Implantation Window

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04323683
Enrollment
12
Registered
2020-03-26
Start date
2019-02-01
Completion date
2019-07-31
Last updated
2020-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fertility

Brief summary

This study evaluates the relationship between progesterone levels and endometrial gene expression

Interventions

GENETICMicroarray

High throughput technique for determining global gene expression of the condition of interest

Sponsors

University of Nottingham
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* Ages 18-35, regular menstrual cycles, the cycle length between 25 and 35 days, body mass index (BMI) between 18 - 25

Exclusion criteria

* History of infertility, history of pelvic pain or/and endometriosis, history of pelvic mass, history of hormonal therapy in the last 3 months

Design outcomes

Primary

MeasureTime frameDescription
Differentially expressed genes between women with low and normal progesterone2 monthsFold-change and p-value were used to determine differentially expressed genes using Partek software

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026